Mateusz K Hołda1, Agata Krawczyk-Ożóg2, Mateusz Koziej3, Danuta Sorysz4, Jakub Hołda3, Dariusz Dudek4, Wiesława Klimek-Piotrowska3. 1. Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland. Electronic address: mkh@onet.eu. 2. Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland; Department of Interventional Cardiology, University Hospital, Jagiellonian University Medical College, Cracow, Poland. 3. Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland. 4. Department of Interventional Cardiology, University Hospital, Jagiellonian University Medical College, Cracow, Poland.
Abstract
BACKGROUND: The atrial septal pouch is an anatomic variant of the interatrial septum. The morphology of the left-sided septal pouch (LSSP) may favor blood stasis and predispose to thromboembolic events. The aim of this study was to determine the association between LSSP presence and cryptogenic stroke. METHODS: A total of 126 consecutive patients with cryptogenic stroke and 137 age-matched control patients without stroke were analyzed retrospectively. The presence and dimensions of LSSPs were assessed using transesophageal echocardiography. RESULTS: LSSP was present in 55.6% of patients with cryptogenic stroke and in 40.9% of those without stroke (P = .02). In univariate analysis, patients with LSSP were more likely to have cryptogenic stroke (odds ratio, 1.81; 95% CI, 1.11-2.95; P = .02). After adjusting for other risk factors using multiple logistic regression, the presence of an LSSP was found to be associated with an increased risk for cryptogenic stroke (odds ratio, 2.02; 95% CI, 1.19-3.41; P = .01). There were no statistically significant differences in size of the LSSP between patients with and those without stroke (P > .05). CONCLUSIONS: There is an association between the presence of an LSSP and an increased risk for cryptogenic stroke. More attention should be paid to clinical evaluations of LSSPs.
BACKGROUND: The atrial septal pouch is an anatomic variant of the interatrial septum. The morphology of the left-sided septal pouch (LSSP) may favor blood stasis and predispose to thromboembolic events. The aim of this study was to determine the association between LSSP presence and cryptogenic stroke. METHODS: A total of 126 consecutive patients with cryptogenic stroke and 137 age-matched control patients without stroke were analyzed retrospectively. The presence and dimensions of LSSPs were assessed using transesophageal echocardiography. RESULTS: LSSP was present in 55.6% of patients with cryptogenic stroke and in 40.9% of those without stroke (P = .02). In univariate analysis, patients with LSSP were more likely to have cryptogenic stroke (odds ratio, 1.81; 95% CI, 1.11-2.95; P = .02). After adjusting for other risk factors using multiple logistic regression, the presence of an LSSP was found to be associated with an increased risk for cryptogenic stroke (odds ratio, 2.02; 95% CI, 1.19-3.41; P = .01). There were no statistically significant differences in size of the LSSP between patients with and those without stroke (P > .05). CONCLUSIONS: There is an association between the presence of an LSSP and an increased risk for cryptogenic stroke. More attention should be paid to clinical evaluations of LSSPs.
Authors: Esmeralci Ferreira; Dinaldo Cavalcanti de Oliveira; Andressa Braga Barros; Valerio Fuks; Ângelo Antunes Salgado; Márcio José Montenegro da Costa; Sara Cristine Marques Dos Santos; Ivana Aragão; Márcia Bueno Castier; Luiz Kohn; Ricardo Mourilhe-Rocha; Felipe N Albuquerque; Roberto Esporcatte; Denilson Campos de Albuquerque Journal: Am J Case Rep Date: 2021-12-20
Authors: David Zisa; Francesco F Faletra; Benjamin S Wessler; Neil J Halin; Pranitha Reddy; Ayan R Patel; Natesa G Pandian Journal: CASE (Phila) Date: 2019-12-04