Astrid Kibleur1, Sonia Pellissier2, Valérie Sinniger3, Jade Robert1, Eloise Gronlier1, Didier Clarençon4, Laurent Vercueil5, Dominique Hoffmann6, Bruno Bonaz3, Olivier David7. 1. Univ. Grenoble Alpes, F-38000 Grenoble, France; Inserm, U1216, Grenoble Institut des Neurosciences, F-38000 Grenoble, France. 2. Univ. Grenoble Alpes, F-38000 Grenoble, France; Laboratoire InterUniversitaire de Psychologie, EA 4145, BP 1104, F-73011 Chambéry, France; Université de Savoie, BP 1104, F-73011 Chambéry, France. 3. Univ. Grenoble Alpes, F-38000 Grenoble, France; Inserm, U1216, Grenoble Institut des Neurosciences, F-38000 Grenoble, France; Service d'Hépato-Gastroentérologie, CHU Grenoble, F-38043, France. 4. Univ. Grenoble Alpes, F-38000 Grenoble, France; Inserm, U1216, Grenoble Institut des Neurosciences, F-38000 Grenoble, France; Institut de Recherche Biomédicale des Armées (IRBA), BP 73, F-91223 Brétigny-sur-Orge, France. 5. Service d'Epilepsie, CHU Grenoble, F-38043, France. 6. Service de Neurochirurgie, CHU Grenoble, F-38043, France. 7. Univ. Grenoble Alpes, F-38000 Grenoble, France; Inserm, U1216, Grenoble Institut des Neurosciences, F-38000 Grenoble, France. Electronic address: Olivier.David@inserm.fr.
Abstract
OBJECTIVES: In the context of the first clinical trial of vagus nerve stimulation (VNS) in Crohn's disease (CD), our main objective was to quantify the acute and chronic effects of VNS on brain activity in CD patients. METHODS: We measured the electroencephalogram (EEG) in 9CD patients under VNS at 10 Hz just before VNS initiation, after 6 weeks and after 12 months of chronic VNS. RESULTS: Acute VNS induced increased spectral power in delta and theta bands on frontal, temporal and occipital electrodes. The main significant modulation was the 12 months' chronic effect of VNS which consisted mainly in a decreased power in the alpha frequency band which was correlated with the normalization of bowel mucosal inflammation, anxiety state and vagal tone. CONCLUSIONS: In addition to the activation of vagal efferent fibers that regulate the autonomic nervous system, our data suggest that chronic VNS has a regulatory action via afferent vagal fibers on anxio-depressive symptomatology associated to CD, which could be directly highlighted by the modulation of EEG alpha power known to be associated to depressed states. SIGNIFICANCE: This is the first report of the central effects of VNS in CD patients.
OBJECTIVES: In the context of the first clinical trial of vagus nerve stimulation (VNS) in Crohn's disease (CD), our main objective was to quantify the acute and chronic effects of VNS on brain activity in CDpatients. METHODS: We measured the electroencephalogram (EEG) in 9CD patients under VNS at 10 Hz just before VNS initiation, after 6 weeks and after 12 months of chronic VNS. RESULTS: Acute VNS induced increased spectral power in delta and theta bands on frontal, temporal and occipital electrodes. The main significant modulation was the 12 months' chronic effect of VNS which consisted mainly in a decreased power in the alpha frequency band which was correlated with the normalization of bowel mucosal inflammation, anxiety state and vagal tone. CONCLUSIONS: In addition to the activation of vagal efferent fibers that regulate the autonomic nervous system, our data suggest that chronic VNS has a regulatory action via afferent vagal fibers on anxio-depressive symptomatology associated to CD, which could be directly highlighted by the modulation of EEG alpha power known to be associated to depressed states. SIGNIFICANCE: This is the first report of the central effects of VNS in CDpatients.
Authors: William L Schuerman; Kirill V Nourski; Ariane E Rhone; Matthew A Howard; Edward F Chang; Matthew K Leonard Journal: Sci Rep Date: 2021-11-23 Impact factor: 4.379
Authors: Riccardo Fornaro; Giovanni Clemente Actis; Gian Paolo Caviglia; Demis Pitoni; Davide Giuseppe Ribaldone Journal: J Clin Med Date: 2022-09-26 Impact factor: 4.964