Yossi Mizrachi1,2, Eran Horowitz3,4, Jacob Farhi3,4, David Levran3,4, Arieh Raziel3,4, Ariel Weissman3,4. 1. IVF Unit, Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, 62 Halochamim St, POB 58100, Holon, Israel. mizrachi.yossi@gmail.com. 2. Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel. mizrachi.yossi@gmail.com. 3. IVF Unit, Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, 62 Halochamim St, POB 58100, Holon, Israel. 4. Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
Abstract
PURPOSE: The clinical significance of serum hCG levels after ovulation triggering was studied previously with conflicting results. Our aim was to study the correlation of hCG levels on the day after ovulation triggering using recombinant hCG (r-hCG) with treatment outcome. METHODS: A prospective observational study of all fresh IVF/ICSI cycles in a single medical center, between January 2015 and June 2016, was performed. hCG serum levels were obtained 10-12 h following ovulation triggering with 250 mcg r-hCG. Clinical and laboratory outcome parameters were compared between cycles with serum hCG above and below median level. A multivariate regression analysis was performed in order to study the association between hCG levels and live birth rate, after controlling for confounders. RESULTS: Overall, 326 cycles were included. Median serum hCG level was 91.35 IU/L. hCG levels were lower as age and BMI were higher (p = 0.004, p < 0.001, respectively). The study groups did not differ with regard to clinical pregnancy rate (p = 0.14), live birth rate (p = 0.09), fertilization rate (p = 0.45), or metaphase II oocyte rate (p = 0.68). On multivariate regression analysis, hCG level was not associated with live birth (aOR 0.99, 95% CI 0.98-1.005), after controlling for patient's age and BMI. CONCLUSIONS: hCG levels on the day after ovulation triggering with 250 mcg r-hCG are inversely correlated with patient age and BMI. However, they are not correlated with any clinical or laboratory outcome parameter. Therefore, testing for hCG levels after ovulation induction seems futile and cannot be recommended.
PURPOSE: The clinical significance of serum hCG levels after ovulation triggering was studied previously with conflicting results. Our aim was to study the correlation of hCG levels on the day after ovulation triggering using recombinant hCG (r-hCG) with treatment outcome. METHODS: A prospective observational study of all fresh IVF/ICSI cycles in a single medical center, between January 2015 and June 2016, was performed. hCG serum levels were obtained 10-12 h following ovulation triggering with 250 mcg r-hCG. Clinical and laboratory outcome parameters were compared between cycles with serum hCG above and below median level. A multivariate regression analysis was performed in order to study the association between hCG levels and live birth rate, after controlling for confounders. RESULTS: Overall, 326 cycles were included. Median serum hCG level was 91.35 IU/L. hCG levels were lower as age and BMI were higher (p = 0.004, p < 0.001, respectively). The study groups did not differ with regard to clinical pregnancy rate (p = 0.14), live birth rate (p = 0.09), fertilization rate (p = 0.45), or metaphase II oocyte rate (p = 0.68). On multivariate regression analysis, hCG level was not associated with live birth (aOR 0.99, 95% CI 0.98-1.005), after controlling for patient's age and BMI. CONCLUSIONS:hCG levels on the day after ovulation triggering with 250 mcg r-hCG are inversely correlated with patient age and BMI. However, they are not correlated with any clinical or laboratory outcome parameter. Therefore, testing for hCG levels after ovulation induction seems futile and cannot be recommended.
Entities:
Keywords:
BMI; Human chorionic gonadotropin; IVF; Outcome
Authors: Douglas T Carrell; Kirtly P Jones; C Matthew Peterson; Vincent Aoki; Benjamin R Emery; Bruce R Campbell Journal: Reprod Biomed Online Date: 2001 Impact factor: 3.828
Authors: Laura Detti; Mohamed F M Mitwally; Anuradha Rode; Frank D Yelian; Michael Kruger; Michael P Diamond; Elizabeth E Puscheck Journal: Fertil Steril Date: 2007-04-06 Impact factor: 7.329
Authors: Carina C W Chan; Ernest H Y Ng; Maureen M Y Chan; Oi Shan Tang; Estella Y L Lau; William S B Yeung; Pak-Chung Ho Journal: Hum Reprod Date: 2003-11 Impact factor: 6.918