Florian Alexander Kerker1, Werner Adler2, Kathrin Brunner3, Tobias Moest1, Matthias C Wurm1, Emeka Nkenke4, Friedrich Wilhelm Neukam1, Cornelius von Wilmowsky5. 1. Department of Oral and Maxillofacial Surgery, University of Erlangen-Nürnberg, Glückstrasse 11, 91054, Erlangen, Germany. 2. Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen-Nürnberg, Waldstraße 6, 91054, Erlangen, Germany. 3. Department of Pathology, University of Erlangen-Nürnberg, Krankenhausstraße 8-10, 91054, Erlangen, Germany. 4. Department of Cranio-, Maxillofacial and Oral Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. 5. Department of Oral and Maxillofacial Surgery, University of Erlangen-Nürnberg, Glückstrasse 11, 91054, Erlangen, Germany. cornelius.vonwilmowsky@uk-erlangen.de.
Abstract
OBJECTIVES: This study aimed to identify anatomical areas where resections of oral squamous cell carcinomas (OSCC) are significantly associated with close or positive margins. MATERIALS AND METHODS: This retrospective study included 330 patients with a primary OSCC from 2010 to 2015. Patient and tumour data were categorised into three groups by R-status (R0 [clear], ≥ 5 mm, 185 patients [56.06%]; R1 [positive], < 1 mm, 24 patients [7.27%]; and R0 [close], 1-5 mm, 121 patients [36.67%]). RESULTS: Areas where resections were significantly associated with close or positive margins were the hard palate (p < 0.001), buccal mucosa (p = 0.03), floor of the mouth (p = 0.004), lower alveolar ridge (p = 0.01), retromolar triangle (p = 0.005), and dorsal tongue (p = 0.02). CONCLUSIONS: Anatomical areas were identified in the oral cavity where it is challenging to resect OSCCs with an adequate safety margin. CLINICAL RELEVANCE: These results may enable surgeons to achieve a postulated safe distance during tumour resection, leading to a survival benefit for patients.
OBJECTIVES: This study aimed to identify anatomical areas where resections of oral squamous cell carcinomas (OSCC) are significantly associated with close or positive margins. MATERIALS AND METHODS: This retrospective study included 330 patients with a primary OSCC from 2010 to 2015. Patient and tumour data were categorised into three groups by R-status (R0 [clear], ≥ 5 mm, 185 patients [56.06%]; R1 [positive], < 1 mm, 24 patients [7.27%]; and R0 [close], 1-5 mm, 121 patients [36.67%]). RESULTS: Areas where resections were significantly associated with close or positive margins were the hard palate (p < 0.001), buccal mucosa (p = 0.03), floor of the mouth (p = 0.004), lower alveolar ridge (p = 0.01), retromolar triangle (p = 0.005), and dorsal tongue (p = 0.02). CONCLUSIONS: Anatomical areas were identified in the oral cavity where it is challenging to resect OSCCs with an adequate safety margin. CLINICAL RELEVANCE: These results may enable surgeons to achieve a postulated safe distance during tumour resection, leading to a survival benefit for patients.
Authors: J Honorato; M S Rebelo; F L Dias; D R Camisasca; P A Faria; G Azevedo e Silva; S Q C Lourenço Journal: Int J Oral Maxillofac Surg Date: 2015-07-14 Impact factor: 2.789
Authors: Moran Amit; Tzu-Chen Yen; Chun-Ta Liao; Pankaj Chaturvedi; Jai Prakash Agarwal; Luiz P Kowalski; Ardalan Ebrahimi; Jonathan R Clark; Matthias Kreppel; Joachim Zöller; Eran Fridman; Villaret A Bolzoni; Jatin P Shah; Yoav Binenbaum; Snehal G Patel; Ziv Gil Journal: Cancer Date: 2013-09-20 Impact factor: 6.860
Authors: David G Pfister; Kie-Kian Ang; David M Brizel; Barbara A Burtness; Paul M Busse; Jimmy J Caudell; Anthony J Cmelak; A Dimitrios Colevas; Frank Dunphy; David W Eisele; Jill Gilbert; Maura L Gillison; Robert I Haddad; Bruce H Haughey; Wesley L Hicks; Ying J Hitchcock; Merrill S Kies; William M Lydiatt; Ellie Maghami; Renato Martins; Thomas McCaffrey; Bharat B Mittal; Harlan A Pinto; John A Ridge; Sandeep Samant; David E Schuller; Jatin P Shah; Sharon Spencer; Randal S Weber; Gregory T Wolf; Frank Worden; Sue S Yom; Nicole R McMillian; Miranda Hughes Journal: J Natl Compr Canc Netw Date: 2013-08 Impact factor: 11.908
Authors: Richard W Nason; Abdulaziz Binahmed; Kumar A Pathak; Ahmed A Abdoh; George K B Sándor Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2009-01-25
Authors: Ling Ma; Maysam Shahedi; Ted Shi; Martin Halicek; James V Little; Amy Y Chen; Larry L Myers; Baran D Sumer; Baowei Fei Journal: Proc SPIE Int Soc Opt Eng Date: 2021-02-15
Authors: Ling Ma; Ximing Zhou; James V Little; Amy Y Chen; Larry L Myers; Baran D Sumer; Baowei Fei Journal: Proc SPIE Int Soc Opt Eng Date: 2021-02-15
Authors: Jan Heidkamp; Willem L J Weijs; Adriana C H van Engen-van Grunsven; Ilse de Laak-de Vries; Marnix C Maas; Maroeska M Rovers; Jurgen J Fütterer; Stefan C A Steens; Robert P Takes Journal: Head Neck Date: 2020-03-02 Impact factor: 3.147