| Literature DB >> 29572395 |
Trish A Gray1,2, Sarah Rhodes2,3, Ross A Atkinson1,2, Katy Rothwell2, Paul Wilson2,4, Jo C Dumville1,2, Nicky A Cullum1,2,5.
Abstract
BACKGROUND: Complex wounds impose a substantial health economic burden worldwide. As wound care is managed across multiple settings by a range of healthcare professionals with varying levels of expertise, the actual care delivered can vary considerably and result in the underuse of evidence-based interventions, the overuse of interventions supported by limited evidence and low value healthcare.Entities:
Keywords: evidence based practice; health services research; healthcare quality; healthcare value; patient-centred care; prevalence survey; wound management
Mesh:
Substances:
Year: 2018 PMID: 29572395 PMCID: PMC5875675 DOI: 10.1136/bmjopen-2017-019440
Source DB: PubMed Journal: BMJ Open ISSN: 2044-6055 Impact factor: 2.692
Key evidence and recommendations related to the assessment, prevention and treatment of complex wounds
| Wound | Key treatments of interest | Guidelines and recommendations |
| Infected | Silver dressings | Insufficient evidence to support the use of silver-containing dressings to promote wound healing or prevent wound infections |
| Honey | Some high-quality evidence (based on two RCTs only) has shown honey to heal partial thickness burns and infected postoperative wounds more quickly than comparators; however, comparators may not be relevant to current practice. Insufficient evidence to support the use of honey in other wounds | |
| Iodine | There is insufficient evidence addressing effectiveness and safety for use of iodine to treat or prevent wound infection. | |
| VLU | ABPI | Measurement of ABPI should be performed by appropriately trained practitioners to substantiate the presence or absence of PAD at initial assessment and to regularly review the use of compression therapy. |
| Compression therapy | Simple non-adherent dressings and high-compression multicomponent bandaging should be used for treating patients with VLU and ABPI ≥0.8. Graduated compression hosiery is recommended to prevent recurrence of VLU. | |
| Pentoxifylline | High-quality evidence, based on systematic review and meta-analysis has found improved VLU healing with the use of pentoxifylline (believed to increase microcirculatory blood flow although exact mechanism of action is unknown) and should be considered in patients with VLU. | |
| Diabetic foot ulcer | Dressing choice | Insufficient evidence to support the use of any specific dressing. Clinical assessment and patient preference should be taken into consideration, while the lowest acquisition cost appropriate to the clinical circumstances should be used. |
| Pressure relief | Offer non-removable casting to offload plantar neuropathic, non-ischaemic, uninfected forefoot and midfoot diabetic ulcers taking into consideration clinical assessment and patient preference. Use pressure redistributing devices and strategies to minimise the risk of pressure ulcers developing. | |
| PU | Dressing choice | Insufficient evidence to support the use of any specific dressing, choice should be determined by the patient’s pain, tolerance, location of the ulcer and amount of exudate. A dressing that promotes a warm, moist wound-healing environment should be considered for grades 2, 3 and 4 PUs. |
| Pressure relief | Use high-specification foam mattresses or consider the use of dynamic support surface if not sufficient. Consider high-specification foam or equivalent pressure redistributing cushion for chair or wheelchair use. |
ABPI, Ankle Brachial Pressure Index; PAD, peripheral arterial disease; PU, pressure ulcer; RCTs, randomised controlled trials; VLU, venous leg ulcer.
Demographic characteristics of patients with at least one complex wound
| Characteristic | |
| Gender (n=2967) | |
| Male: n (%) | 1439 (49) |
| Female: n (%) | 1528 (51) |
| Ethnicity (n=3152) | |
| White British: n (%) | 2819 (89) |
| Other: n (%) | 336 (11) |
| Age (n=3120) | |
| Median (range) | 74 (1–107) |
| Accommodation (n=3157) | |
| Own/rented home: n (%) | 2728 (86) |
| Nursing/residential home: n (%) | 348 (11) |
| Other: n (%) | 84 (3) |
| Number of comorbidities (n=3179) | |
| Median (range) | 1 (0–9) |
| Continence (n=3029) | |
| No incontinence: n (%) | 2487 (82) |
| Urinary or faecal incontinence or both: n (%) | 542 (18) |
| Mobility (n=3141) | |
| Fully mobile: n (%) | 1613 (51) |
| Walks with difficulty: n (%) | 1091 (35) |
| Immobile: n (%) | 437 (14) |
| Community point prevalence per 10 000 population for most common wound types: n (CPP; 95% CI) | |
| Venous leg ulcer | 612 (3.2; 2.9 to 3.4) |
| Diabetic foot ulcer | 488 (2.5; 2.3 to 2.7) |
| Traumatic wound | 428 (2.2; 2.0 to 2.4) |
| Pressure ulcer | 348 (1.8; 1.6 to 2.0) |
CPP, community point prevalence.
Figure 1Proportion of complex wounds for which primary dressing contained antimicrobials: the other antimicrobial dressing group maps to the same section of the British National Formulary and includes dressings such as polyhexanide polyhexamethylene biguanide (bars represent included community services). Number of patients per community service ranged from 172 to 655.
Figure 2Highest level of compression used for patients with VLUs selected as most severe wound (bars represent included community services). Number of patients per community service ranged from 14 to 151. VLU, venous leg ulcer.
Figure 3Proportion of patients using pressure-relieving mattresses or cushions (bars represent included community services). Number of patients per community service ranged from 10 to 63.