Literature DB >> 29572156

The WNT signaling pathways in wound healing and fibrosis.

Olivier Burgy1, Melanie Königshoff2.   

Abstract

The WNT signaling pathways are major regulators of organ development. Ample research over the past few decades revealed that these pathways are critically involved in adult tissue homeostasis and stem cell function as well as the development of chronic diseases, such as cancer and fibrosis. In this review, we will describe the different WNT signal pathways, summarize the current evidence of WNT signal involvement in wound healing and fibrosis, and highlight potential novel therapeutic options for fibrotic disorders targeting WNT signaling pathways.
Copyright © 2017 International Society of Matrix Biology. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cell reprogramming; Fibrosis; Repair; Tissue regeneration; WNT signaling

Mesh：

Substances：

Year:  2018        PMID： 29572156     DOI： 10.1016/j.matbio.2018.03.017

Source DB:  PubMed          Journal:  Matrix Biol        ISSN： 0945-053X            Impact factor:   11.583


  46 in total

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4.  Rethinking carcinogenesis: The detached pericyte hypothesis.

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Authors:  Bethan L Thomas; Suzanne E Eldridge; Babak Nosrati; Mario Alvarez; Anne-Sophie Thorup; Giovanna Nalesso; Sara Caxaria; Aida Barawi; James G Nicholson; Mauro Perretti; Carles Gaston-Massuet; Costantino Pitzalis; Alison Maloney; Adrian Moore; Ray Jupp; Francesco Dell'Accio
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Review 10.  Shared and distinct mechanisms of fibrosis.

Authors:  Jörg H W Distler; Andrea-Hermina Györfi; Meera Ramanujam; Michael L Whitfield; Melanie Königshoff; Robert Lafyatis
Journal:  Nat Rev Rheumatol       Date:  2019-11-11       Impact factor: 20.543
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