Sreeja Biswas Roy1, Shaimaa Elnahas1, Rosemarie Serrone2, Cassandra Haworth3, Michael T Olson4, Paul Kang5, Michael A Smith1, Ross M Bremner1, Jasmine L Huang6. 1. Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, Ariz. 2. Department of General Surgery, St. Joseph's Hospital and Medical Center, Phoenix, Ariz. 3. A.T. Still University School of Osteopathic Medicine, Mesa, Ariz. 4. Grand Canyon University, Phoenix, Ariz. 5. University of Arizona College of Public Health, Phoenix, Ariz. 6. Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, Ariz. Electronic address: Jasmine.Huang@dignityhealth.org.
Abstract
OBJECTIVES: Gastroesophageal reflux disease (GERD) is prevalent after lung transplantation. Fundoplication slows lung function decline in patients with GERD, but the optimal timing of fundoplication is unknown. METHODS: We retrospectively reviewed patients who underwent fundoplication after lung transplantion at our center from April 2007 to July 2014. Patients were divided into 2 groups: early fundoplication (<6 months after lung transplantation) and late fundoplication (≥6 months after lung transplantation). Annual decline in percent predicted forced expiratory volume in 1 second (FEV1) was analyzed. RESULTS: Of the 251 patients who underwent lung transplantation during the study period with available pH data, 86 (34.3%) underwent post-transplantation fundoplication for GERD. Thirty of 86 (34.9%) had early fundoplication and 56 of 86 (65.1%) had late fundoplication. Median time from lung transplantation to fundoplication was 4.6 months (interquartile range, 2.0-5.2) and 13.8 months (interquartile range, 9.0-16.1) for the early and late groups, respectively. The median DeMeester score was comparable between groups. One-, 3-, and 5-year actuarial survival rates in the early group were 90%, 70%, and 70%, respectively; in the late group, these rates were 91%, 66%, and 66% (log rank P = .60). Three- and 5-year percent predicted FEV1 was lower in the late group by 8.9% (95% confidence interval, -30.2 to 12.38; P = .46) and 40.7% (95% confidence interval, -73.66 to -7.69; P = .019). A linear mixed model showed a 5.7% lower percent predicted FEV1 over time in the late fundoplication group (P < .001). CONCLUSIONS: In this study, patients with early fundoplication had a higher FEV1 5 years after lung transplantation. Early fundoplication might protect against GERD-induced lung damage in lung transplant recipients with GERD.
OBJECTIVES:Gastroesophageal reflux disease (GERD) is prevalent after lung transplantation. Fundoplication slows lung function decline in patients with GERD, but the optimal timing of fundoplication is unknown. METHODS: We retrospectively reviewed patients who underwent fundoplication after lung transplantion at our center from April 2007 to July 2014. Patients were divided into 2 groups: early fundoplication (<6 months after lung transplantation) and late fundoplication (≥6 months after lung transplantation). Annual decline in percent predicted forced expiratory volume in 1 second (FEV1) was analyzed. RESULTS: Of the 251 patients who underwent lung transplantation during the study period with available pH data, 86 (34.3%) underwent post-transplantation fundoplication for GERD. Thirty of 86 (34.9%) had early fundoplication and 56 of 86 (65.1%) had late fundoplication. Median time from lung transplantation to fundoplication was 4.6 months (interquartile range, 2.0-5.2) and 13.8 months (interquartile range, 9.0-16.1) for the early and late groups, respectively. The median DeMeester score was comparable between groups. One-, 3-, and 5-year actuarial survival rates in the early group were 90%, 70%, and 70%, respectively; in the late group, these rates were 91%, 66%, and 66% (log rank P = .60). Three- and 5-year percent predicted FEV1 was lower in the late group by 8.9% (95% confidence interval, -30.2 to 12.38; P = .46) and 40.7% (95% confidence interval, -73.66 to -7.69; P = .019). A linear mixed model showed a 5.7% lower percent predicted FEV1 over time in the late fundoplication group (P < .001). CONCLUSIONS: In this study, patients with early fundoplication had a higher FEV1 5 years after lung transplantation. Early fundoplication might protect against GERD-induced lung damage in lung transplant recipients with GERD.
Authors: Jordan Burlen; Suma Chennubhotla; Shifat Ahmed; Sarah Landes; Allan Ramirez; Abigail M Stocker; Thomas L Abell Journal: Gastroenterology Res Date: 2022-06-22
Authors: Chen Yang Kevin Zhang; Musawir Ahmed; Ella Huszti; Liran Levy; Sarah E Hunter; Kristen M Boonstra; Sajad Moshkelgosha; Andrew T Sage; Sassan Azad; Rasheed Ghany; Jonathan C Yeung; Oscar M Crespin; Lianne G Singer; Shaf Keshavjee; Tereza Martinu Journal: Respir Res Date: 2022-08-26
Authors: Ashwini Arjuna; Michael T Olson; Rajat Walia; Ross M Bremner; Michael A Smith; Thalachallour Mohanakumar Journal: Expert Rev Respir Med Date: 2020-10-25 Impact factor: 3.772
Authors: Andreacarola Urso; Miguel M Leiva-Juárez; Domenica F Briganti; Beatrice Aramini; Luke Benvenuto; Joseph Costa; Renu Nandakumar; Estela Area Gomez; Hilary Y Robbins; Lori Shah; Meghan Aversa; Joshua R Sonnet; Selim Arcasoy; Serge Cremers; Frank D'Ovidio Journal: J Heart Lung Transplant Date: 2021-05-28 Impact factor: 13.569