A I Rupérez1, J Olza2, M Gil-Campos3, R Leis4, G Bueno5, C M Aguilera2, A Gil2, L A Moreno6. 1. Growth, Exercise, NUtrition and Development (GENUD) Research Group, University of Zaragoza, Food and Agriculture Institute of Aragón (IA2), Health Research Institute of Aragón (ISS Aragón), Zaragoza, Spain. Electronic address: airuperez@unizar.es. 2. Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, University of Granada, Biomedical Research Institute ibs, Granada, Spain; CIBER Obesity and Nutrition Physiopathology (CIBEROBN), Madrid, Spain. 3. CIBER Obesity and Nutrition Physiopathology (CIBEROBN), Madrid, Spain; Paediatric Research and Metabolism Unit, Reina Sofía University Hospital, Maimonides Institute for Biomedical Research of Córdoba (IMBIC), Córdoba, Spain. 4. CIBER Obesity and Nutrition Physiopathology (CIBEROBN), Madrid, Spain; Unit of Investigation in Nutrition, Growth and Human Development of Galicia, Paediatric Department, Health Research Institute of Santiago (IDIS), University of Santiago de Compostela, Galicia, Spain. 5. CIBER Obesity and Nutrition Physiopathology (CIBEROBN), Madrid, Spain; Paediatric Department, Lozano Blesa University Hospital, University of Zaragoza, Food and Agriculture Institute of Aragón (IA2), Health Research Institute of Aragón (ISS Aragón), Zaragoza, Spain. 6. Growth, Exercise, NUtrition and Development (GENUD) Research Group, University of Zaragoza, Food and Agriculture Institute of Aragón (IA2), Health Research Institute of Aragón (ISS Aragón), Zaragoza, Spain; CIBER Obesity and Nutrition Physiopathology (CIBEROBN), Madrid, Spain.
Abstract
BACKGROUND AND AIMS: The early onset of cardio-metabolic abnormalities, known as metabolically unhealthy (MU) status, is highly associated with obesity and cardiovascular disease (CVD), as well as with increased morbidity and mortality later in life. Given the lack of a consensus MU classification for prepubertal children, we aimed to compare available MU definitions in terms of their association with CVD risk biomarkers. METHODS AND RESULTS: A total of 930 prepubertal children (622 with overweight/obesity, 462 males) aged 5-10.9 years were recruited, anthropometric measures were taken and biomarkers were analyzed. Children were classified using eight MU definitions based on different cut-offs for blood pressure, triacylglycerides, high-density lipoprotein cholesterol, glucose and homeostasis model assessment for insulin resistance (HOMA-IR). MU prevalence in children with overweight/obesity ranged between 30% and 60% across definitions. Plasma concentrations of resistin, leptin, myeloperoxidase (MPO) and total plasminogen activator inhibitor 1 (tPAI-1) were higher, and those of adiponectin were lower, in MU compared to MH children with overweight/obesity. Linear regression analyses confirmed the contribution of MPO and tPAI-1 concentrations to MU status, with most significant results derived from definitions that use age and sex-specific criteria and that account for HOMA-IR. CONCLUSION: Plasma concentrations of MPO and tPAI-1 are increased in prepubertal MU children irrespective of having normal-weight or overweight/obesity. Inclusion of age and sex-specific cut-offs for cardio-metabolic components as well as insulin resistance criteria increases the quality of MU definitions as seen by their stronger association with CVD biomarkers concentrations.
BACKGROUND AND AIMS: The early onset of cardio-metabolic abnormalities, known as metabolically unhealthy (MU) status, is highly associated with obesity and cardiovascular disease (CVD), as well as with increased morbidity and mortality later in life. Given the lack of a consensus MU classification for prepubertal children, we aimed to compare available MU definitions in terms of their association with CVD risk biomarkers. METHODS AND RESULTS: A total of 930 prepubertal children (622 with overweight/obesity, 462 males) aged 5-10.9 years were recruited, anthropometric measures were taken and biomarkers were analyzed. Children were classified using eight MU definitions based on different cut-offs for blood pressure, triacylglycerides, high-density lipoprotein cholesterol, glucose and homeostasis model assessment for insulin resistance (HOMA-IR). MU prevalence in children with overweight/obesity ranged between 30% and 60% across definitions. Plasma concentrations of resistin, leptin, myeloperoxidase (MPO) and total plasminogen activator inhibitor 1 (tPAI-1) were higher, and those of adiponectin were lower, in MU compared to MH children with overweight/obesity. Linear regression analyses confirmed the contribution of MPO and tPAI-1 concentrations to MU status, with most significant results derived from definitions that use age and sex-specific criteria and that account for HOMA-IR. CONCLUSION: Plasma concentrations of MPO and tPAI-1 are increased in prepubertal MU children irrespective of having normal-weight or overweight/obesity. Inclusion of age and sex-specific cut-offs for cardio-metabolic components as well as insulin resistance criteria increases the quality of MU definitions as seen by their stronger association with CVD biomarkers concentrations.
Authors: Francisco Jesús Llorente-Cantarero; Rosaura Leis; Azahara I Rupérez; Augusto Anguita-Ruiz; Rocío Vázquez-Cobela; Katherine Flores-Rojas; Esther M González-Gil; Concepción M Aguilera; Luis A Moreno; Mercedes Gil-Campos; Gloria Bueno Journal: Front Nutr Date: 2022-04-12
Authors: Rosaura Leis; Jose Manuel Jurado-Castro; Francisco Jesus Llorente-Cantarero; Augusto Anguita-Ruiz; Azahara Iris-Rupérez; Juan Jose Bedoya-Carpente; Rocío Vázquez-Cobela; Concepción María Aguilera; Gloria Bueno; Mercedes Gil-Campos Journal: Nutrients Date: 2020-05-01 Impact factor: 5.717