Franziska Büsing1, Franziska A Hägele1, Alessa Nas2, Laura-Verena Döbert3, Alena Fricker3, Elisabeth Dörner3, Daniel Podlesny3, Julian Aschoff4, Tobias Pöhnl4, Ralf Schweiggert4, W Florian Fricke3, Reinhold Carle5, Anja Bosy-Westphal6. 1. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany; Institute of Human Nutrition and Food Science, University of Kiel, Germany. 2. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany. 3. Institute of Biological Chemistry and Nutritional Science, University of Hohenheim, Stuttgart, Germany. 4. Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany. 5. Institute of Food Science and Biotechnology, University of Hohenheim, Stuttgart, Germany; Biological Science Department, King Abdulaziz University, Jeddah, Saudi Arabia. 6. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany; Institute of Human Nutrition and Food Science, University of Kiel, Germany. Electronic address: abosyw@nutrition.uni-kiel.de.
Abstract
BACKGROUND: Higher consumption of sugar-containing beverages has been associated with an elevated risk of type 2 diabetes and gout. Whether this equally applies to cola with an unhealthy image and orange juice (OJ) having a healthy image remains unknown. METHODS: In order to investigate whether OJ and cola differently affect metabolic risk26 healthy adults (24.7 ± 3.2 y; BMI 23.2 ± 3.3 kg/m2) participated in a 2 × 2-wk intervention and consumed eitherOJ or caffeine-free cola (20% Ereq as sugar from beverages) in-between 3 meals/d at ad libitum energy intake. Glycemic control, uric acid metabolism and gut microbiota were assessed as outcome parameters. RESULTS:Fecal microbiota, body weight, basal and OGTT-derived insulin sensitivity remained unchanged in both intervention periods. Levels of uric acid were normal at baseline and did not change with 2-wk cola consumption (-0.03 ± 0.67 mg/dL; p > 0.05), whereas they decreased with OJ intervention (-0.43 ± 0.56 mg/dL; p < 0.01) due to increased uric acid excretion (+130.2 ± 130.0 mg/d; p < 0.001). Compared to OJ, consumption of cola led to a higher daylong glycemia (ΔiAUC: 36.9 ± 83.2; p < 0.05), an increase in glucose variability (ΔMAGE-Index: 0.29 ± 0.44; p < 0.05), and a lower 24 h-insulin secretion (ΔC-peptide excretion: -31.76 ± 38.61 μg/d; p < 0.001), which may be explained by a decrease in serum potassium levels (-0.11 ± 0.24 mmol/L; p < 0.05). CONCLUSION: Despite its sugar content, regular consumption of large amounts of OJ do not increase the risk of gout but may even contribute to lower uric acid levels. The etiology of impaired insulin secretion with cola consumption needs to be further investigated.
RCT Entities:
BACKGROUND: Higher consumption of sugar-containing beverages has been associated with an elevated risk of type 2 diabetes and gout. Whether this equally applies to cola with an unhealthy image and orange juice (OJ) having a healthy image remains unknown. METHODS: In order to investigate whether OJ and cola differently affect metabolic risk 26 healthy adults (24.7 ± 3.2 y; BMI 23.2 ± 3.3 kg/m2) participated in a 2 × 2-wk intervention and consumed either OJ or caffeine-free cola (20% Ereq as sugar from beverages) in-between 3 meals/d at ad libitum energy intake. Glycemic control, uric acid metabolism and gut microbiota were assessed as outcome parameters. RESULTS: Fecal microbiota, body weight, basal and OGTT-derived insulin sensitivity remained unchanged in both intervention periods. Levels of uric acid were normal at baseline and did not change with 2-wk cola consumption (-0.03 ± 0.67 mg/dL; p > 0.05), whereas they decreased with OJ intervention (-0.43 ± 0.56 mg/dL; p < 0.01) due to increased uric acid excretion (+130.2 ± 130.0 mg/d; p < 0.001). Compared to OJ, consumption of cola led to a higher daylong glycemia (ΔiAUC: 36.9 ± 83.2; p < 0.05), an increase in glucose variability (ΔMAGE-Index: 0.29 ± 0.44; p < 0.05), and a lower 24 h-insulin secretion (ΔC-peptide excretion: -31.76 ± 38.61 μg/d; p < 0.001), which may be explained by a decrease in serum potassium levels (-0.11 ± 0.24 mmol/L; p < 0.05). CONCLUSION: Despite its sugar content, regular consumption of large amounts of OJ do not increase the risk of gout but may even contribute to lower uric acid levels. The etiology of impaired insulin secretion with cola consumption needs to be further investigated.
Authors: Sabrina Ayoub-Charette; Laura Chiavaroli; Qi Liu; Tauseef Ahmad Khan; Andreea Zurbau; Fei Au-Yeung; Annette Cheung; Amna Ahmed; Danielle Lee; Vivian L Choo; Sonia Blanco Mejia; Russell J de Souza; Thomas Ms Wolever; Lawrence A Leiter; Cyril Wc Kendall; David Ja Jenkins; John L Sievenpiper Journal: J Nutr Date: 2021-08-07 Impact factor: 4.687