Literature DB >> 2957129

Regulatory role of FcR+ and FcR- monocyte subsets in Mycobacterium leprae-induced lymphoproliferative response in vitro.

S Ohkawa, L N Martin, Y Fukunishi, B J Gormus.   

Abstract

We investigated nine rhesus monkeys (Macaca mulatta) inoculated with Mycobacterium leprae and three normal human contacts. Peripheral blood monocytes were separated into Fc receptor positive (FcR+) and Fc receptor negative (FcR-) fractions, and their regulatory role in the lymphoproliferative response in vitro to M. leprae was studied. FcR- monocytes had strong antigen presentation activity and produced no suppressor effect while FcR+ monocytes had weak antigen presentation activity and produced a non-specific suppressor factor spontaneously. With this assay system we determined that M. leprae-inoculated rhesus monkeys could be divided into three groups: good responders, very weak responders, and non-responders.

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Year:  1987        PMID： 2957129      PMCID： PMC1542573     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  22 in total

1.  An improved rosetting assay for detection of human T lymphocytes.

Authors:  M E Kaplan; C Clark
Journal:  J Immunol Methods       Date:  1974-07       Impact factor: 2.303

2.  Structure and antigenicity of the major specific glycolipid antigen of Mycobacterium leprae.

Authors:  S W Hunter; T Fujiwara; P J Brennan
Journal:  J Biol Chem       Date:  1982-12-25       Impact factor: 5.157

3.  The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy.

Authors:  I Nath; R Singh
Journal:  Clin Exp Immunol       Date:  1980-09       Impact factor: 4.330

4.  Freeze-etching study of human and murine leprosy bacilli.

Authors:  M Nishiura; S Izumi; T Mori; K Takeo; T Nonaka
Journal:  Int J Lepr Other Mycobact Dis       Date:  1977 Jul-Sep

5.  Effect of Mycobacterium leprae on lymphocyte proliferation: suppression of mitogen and antigen responses of human peripheral blood mononuclear cells.

Authors:  J Touw; G L Stoner; A Belehu
Journal:  Clin Exp Immunol       Date:  1980-09       Impact factor: 4.330

6.  Binding of phosphatidylethanolamine and phosphatidylinositol to OKT8+ lymphocytes activates suppressor cell activity.

Authors:  A A Wadee; A R Rabson
Journal:  J Immunol       Date:  1983-05       Impact factor: 5.422

7.  Characterization of a suppressor cell-activating factor (SCAF) released by adherent cells treated with M. tuberculosis.

Authors:  A A Wadee; D Mendelsohn; A R Rabson
Journal:  J Immunol       Date:  1983-05       Impact factor: 5.422

8.  Functional subsets of human monocytes defined by monoclonal antibodies: a distinct subset of monocytes contains the cells capable of inducing the autologous mixed lymphocyte culture.

Authors:  H H Shen; M A Talle; G Goldstein; L Chess
Journal:  J Immunol       Date:  1983-02       Impact factor: 5.422

9.  Production of a suppressor factor by human adherent cells treated with mycobacteria.

Authors:  A A Wadee; R Sher; A R Rabson
Journal:  J Immunol       Date:  1980-09       Impact factor: 5.422

10.  Human dendritic cells. Enrichment and characterization from peripheral blood.

Authors:  W C Van Voorhis; L S Hair; R M Steinman; G Kaplan
Journal:  J Exp Med       Date:  1982-04-01       Impact factor: 14.307
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  2 in total

1.  FcR+ and FcR- monocytes differentially secrete monokines during pokeweed mitogen-induced T-cell-monocyte interactions.

Authors:  J Pryjma; B Mytar; H Loppnow; M Ernst; M Zembala; H D Flad
Journal:  Immunology       Date:  1992-02       Impact factor: 7.397

2.  Bacillus Calmette-Guérin (BCG) vaccine generates immunoregulatory cells in the cervical lymph nodes in guinea pigs injected intra dermally.

Authors:  Souzan Vergkizi; Ioannis Nikolakakis
Journal:  Vaccine       Date:  2020-10-16       Impact factor: 4.169
  2 in total

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