Literature DB >> 2956989

Nanomolar concentrations of Cd2+ inhibit Ca2+ transport systems in plasma membranes and intracellular Ca2+ stores in intestinal epithelium.

P M Verbost, M H Senden, C H van Os.   

Abstract

The interactions of Cd2+ with active Ca2+ transport systems in rat intestinal epithelial cells have been investigated. ATP-driven Ca2+ transport in basolateral plasma membrane vesicles was inhibited by Cd2+ with an I50 value of 1.6 nM free Cd2+ at 1 microM free Ca2+, using EGTA and HEEDTA to buffer Ca2+ and Cd2+ concentrations, respectively. The inhibition was competitive in nature since the Km value of Ca2+ increased with increasing Cd2+ concentrations while the Vmax remained constant. Cd2+ had similar effects on ATP-dependent Ca2+ uptake by permeabilized enterocytes, indicating that non-mitochondrial and mitochondrial Ca2+ stores are also inhibited by nanomolar concentrations of Cd2+. We conclude that ATP-driven Ca2+ transport systems are the most sensitive elements so far reported in Cd2+ intoxication.

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Year:  1987        PMID： 2956989     DOI： 10.1016/0005-2736(87)90302-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  Actions of cadmium on basolateral plasma membrane proteins involved in calcium uptake by fish intestine.

Authors:  T J Schoenmakers; P H Klaren; G Flik; R A Lock; P K Pang; S E Bonga
Journal:  J Membr Biol       Date:  1992-05       Impact factor: 1.843

2.  Inhibition of corneal epithelial cell migration by cadmium and mercury.

Authors:  J L Ubels; T B Osgood
Journal:  Bull Environ Contam Toxicol       Date:  1991-02       Impact factor: 2.151

3.  Ca(2+)-independent form of protein kinase C may regulate Na+ transport across frog skin.

Authors:  M M Civan; A Oler; K Peterson-Yantorno; K George; T G O'Brien
Journal:  J Membr Biol       Date:  1991-04       Impact factor: 1.843

4.  Cadmium inhibits plasma membrane calcium transport.

Authors:  P M Verbost; G Flik; R A Lock; S E Wendelaar Bonga
Journal:  J Membr Biol       Date:  1988-05       Impact factor: 1.843

5.  Effects of cadmium in freshwater clams. I. Interaction with essential elements inAnodonta cygnea.

Authors:  J Hemelraad; D A Holwerda; H J Wijnne; D I Zandee
Journal:  Arch Environ Contam Toxicol       Date:  1990 Sep-Oct       Impact factor: 2.804

Review 6.  Molecular and ionic mimicry and the transport of toxic metals.

Authors:  Christy C Bridges; Rudolfs K Zalups
Journal:  Toxicol Appl Pharmacol       Date:  2005-05-01       Impact factor: 4.219

7.  Effects of ambient cadmium with calcium on mRNA expressions of calcium uptake related transporters in zebrafish (Danio rerio) larvae.

Authors:  Chih-Tsen Liu; Ming-Yi Chou; Chia-Hao Lin; Su Mei Wu
Journal:  Fish Physiol Biochem       Date:  2011-12-17       Impact factor: 2.794

8.  Transport of calcium across the dually perfused placenta of the rat.

Authors:  J Stulc; B Stulcová; J Svihovec
Journal:  J Physiol       Date:  1990-01       Impact factor: 5.182

Review 9.  On the mechanism of cellular cadmium uptake.

Authors:  E C Foulkes
Journal:  Biol Trace Elem Res       Date:  1989 Jul-Sep       Impact factor: 3.738

10.  Metal transport in cells: cadmium uptake by rat hepatocytes and renal cortical epithelial cells.

Authors:  Z A Shaikh; M E Blazka; T Endo
Journal:  Environ Health Perspect       Date:  1995-02       Impact factor: 9.031
  10 in total

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