Xinyi Geng1, Xin Xu2, Andreas Horn3, Ningfei Li4, Zhipei Ling5, Peter Brown6, Shouyan Wang7. 1. Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China; University of Chinese Academy of Sciences, Beijing, China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. 2. Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China. 3. Department of Neurology, Movement Disorders Unit, Charité - University Medicine (CVK), Berlin, Germany. 4. Department of Neurology, Movement Disorders Unit, Charité - University Medicine (CVK), Berlin, Germany; Neural Information Processing Group, Institute of Software Engineering and Theoretical Computer Science, Technische Universität Berlin, Berlin, Germany. 5. Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China. Electronic address: lzp301hos@126.com. 6. MRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK. 7. Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China. Electronic address: shouyan@fudan.edu.cn.
Abstract
OBJECTIVE: This study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency. METHODS: Pre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson's disease (PD) who underwent DBS in the subthalamic nucleus and intra-operative LFP recording at rest and during cued movements. Images were reconstructed and 3-D visualized using Lead-DBS® toolbox to determine the coordinates of contact. The resting spectral power and movement-related power modulation of LFP oscillations were estimated. RESULTS: Both subthalamic LFP activity recorded at rest and its modulation by movement had focal maxima in the alpha, beta and gamma bands. The spatial distribution of alpha band activity and its modulation was significantly different to that in the beta band. Moreover, there were significant differences in the scale and timing of movement related modulation across the frequency bands. CONCLUSION: Subthalamic LFP activities within specific frequency bands can be distinguished by spatial topography and pattern of movement related modulation. SIGNIFICANCE: Assessment of the frequency, focality and pattern of movement related modulation of subthalamic LFPs reveals a heterogeneity of neural population activity in this region. This could potentially be leveraged to finesse intra-operative targeting and post-operative contact selection.
OBJECTIVE: This study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency. METHODS: Pre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson's disease (PD) who underwent DBS in the subthalamic nucleus and intra-operative LFP recording at rest and during cued movements. Images were reconstructed and 3-D visualized using Lead-DBS® toolbox to determine the coordinates of contact. The resting spectral power and movement-related power modulation of LFP oscillations were estimated. RESULTS: Both subthalamic LFP activity recorded at rest and its modulation by movement had focal maxima in the alpha, beta and gamma bands. The spatial distribution of alpha band activity and its modulation was significantly different to that in the beta band. Moreover, there were significant differences in the scale and timing of movement related modulation across the frequency bands. CONCLUSION: Subthalamic LFP activities within specific frequency bands can be distinguished by spatial topography and pattern of movement related modulation. SIGNIFICANCE: Assessment of the frequency, focality and pattern of movement related modulation of subthalamic LFPs reveals a heterogeneity of neural population activity in this region. This could potentially be leveraged to finesse intra-operative targeting and post-operative contact selection.
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