Luiza Ianny de Lima1, Karen Rapp Py-Daniel1, Maria Adelaide Guimarães2,3,4, Luís Alexandre Muehlmann1,5, Ana Carolina Mafud6,7, Yvonne Primerano Mascarenhas6, Josué de Moraes8, José Roberto de Souza de Almeida Leite9, Cheng-Shi Jiang10, Ricardo Bentes Azevedo1, João Paulo Figueiró Longo1. 1. Genetics & Morphology Department, Institute of Biological Science, University of Brasilia, Brasília, Brazil. 2. Phytobios Pesquisa Desenvolvimento e Inovação LTDA, Parnaíba, Piauí, Brazil. 3. Núcleo de Pesquisa em Biodiversidade e Biotecnologia, BIOTEC, Universidade Federal do Piauí, Parnaíba, Piauí, Brazil. 4. Programa de pós-graduação em Biotecnologia, RENORBIO, Ponto Focal Universidade Federal do Piauí, Teresina, Piauí, Brasil. 5. Faculty of Ceilandia, University of Brasilia, Brasilia 72220-900, Brazil. 6. Instituto de Física de São Carlos, Departamento de Física e Ciência Interdisciplinar, Universidade de São Paulo, São Carlos - SP, 13566-590, Brazil. 7. Department Medical Parasitology & Infection Biology, Swiss Tropical & Public Health Institute, Basel, 4051, Switzerland. 8. Núcleo de Pesquisa em Doenças Negligenciadas, Universidade Guarulhos, Praça Tereza Cristina, 88, 07023-070, Guarulhos, SP, Brazil. 9. Area Morphology, Faculty of Medicine, University of Brasília (UnB), University Campus Darcy Ribeiro, Asa Norte, 70910-900, Brasília-DF, Brazil. 10. School of Biological Science & Technology, University of Jinan, Jinan 250022, PR China.
Abstract
AIM: To develop a self-nanoemulsifying drug-delivery system (SNEDDS) able to improve oral absorption of epiisopiloturine (EPI), and test the antischistosomal activity in a mice model. RESULTS: SNEDDS had a nanoscopic size and was able to enhance EPI bioavailability after oral administration, and SNEDDS-EPI (40 mg.kg-1) improved the in vivo antischistosomal activity of EPI, demonstrating that SNEDDS was able to improve the pharmacokinetics of EPI, and to maintain the pharmacodynamic activity against Schistosoma mansoni in vivo. CONCLUSION: Taken together, these results indicate that SNEDDS-EPI is efficient in reducing worm burden in comparison to treatment with the free version of EPI. [Formula: see text].
AIM: To develop a self-nanoemulsifying drug-delivery system (SNEDDS) able to improve oral absorption of epiisopiloturine (EPI), and test the antischistosomal activity in a mice model. RESULTS: SNEDDS had a nanoscopic size and was able to enhance EPI bioavailability after oral administration, and SNEDDS-EPI (40 mg.kg-1) improved the in vivo antischistosomal activity of EPI, demonstrating that SNEDDS was able to improve the pharmacokinetics of EPI, and to maintain the pharmacodynamic activity against Schistosoma mansoni in vivo. CONCLUSION: Taken together, these results indicate that SNEDDS-EPI is efficient in reducing worm burden in comparison to treatment with the free version of EPI. [Formula: see text].
Entities:
Keywords:
antischistosomal activity; oral absorption; self-nanoemulsifying drug-delivery systems
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