| Literature DB >> 29564656 |
Kyria Jayanne Clímaco Cruz1, Ana Raquel Soares de Oliveira1, Jennifer Beatriz Silva Morais1, Juliana Soares Severo1, Priscyla Maria Vieira Mendes1, Stéfany Rodrigues de Sousa Melo1, Gustavo Santos de Sousa2, Dilina do Nascimento Marreiro3.
Abstract
Studies have shown the participation of minerals in mechanisms involved in the pathogenesis of insulin resistance. Zinc, in particular, seems to play an important role in the secretion and action of this hormone. Therefore, the aim of this review is to understand the role of zinc in increasing insulin sensitivity. We conducted a search of articles published in the PubMed and ScienceDirect database selected from March 2016 to February 2018, using the keywords "zinc," "insulin," "insulin resistance," "insulin sensitivity," and "supplementation." Following the eligibility criteria were selected 53 articles. The scientific evidences presented in this review show the importance of zinc and their carrier proteins in the synthesis and secretion of insulin, as well as in the signaling pathway of action of this hormone. Zinc deficiency is associated with glucose intolerance and insulin resistance; however, the effectiveness of the intervention with the zinc supplementation is still inconclusive.Entities:
Keywords: Insulin resistance; Insulin secretion; Insulin sensitivity; Supplementation; Zinc
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Year: 2018 PMID： 29564656 DOI： 10.1007/s12011-018-1308-z
Source DB: PubMed Journal: Biol Trace Elem Res ISSN： 0163-4984 Impact factor: 3.738