| Literature DB >> 29564561 |
Yoshihito Nakagawa1, Yukihiro Akao2, Tomomitsu Tahara3, Hiromi Yamashita3, Mitsuo Nagasaka3, Tomoyuki Shibata3, Naoki Ohmiya3.
Abstract
Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P). We tried to clarify the relationship between the expression of the miRNAs and the colorectal tumor development. The expression levels of miR-143, -145, and -34a were reduced in most of the polypoid and FAP tumors compared with those in the flat elevated, UCAT, SSA/P ones. In type 2 adenocarcinomas, the expression profile of these miRNAs was similar to those of the polypoid and FAP tumors. The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors. These findings indicated that the expression of onco-related miRNAs was closely associated with the development and endoscopic appearance of colorectal tumors.Entities:
Keywords: Adenoma–carcinoma sequence; Colorectal tumor development; Flat elevated tumor; Onco-related microRNA; Sessile serrated adenoma/polyp; Ulcerative colitis-associated tumor
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Year: 2018 PMID： 29564561 DOI： 10.1007/s00795-018-0186-y
Source DB: PubMed Journal: Med Mol Morphol ISSN： 1860-1499 Impact factor: 2.309