Ana Filipa Geraldo1,2, João Pereira3, Pedro Nunes4, Sofia Reimão4,5, Rita Sousa4,5, Miguel Castelo-Branco3, Susana Pinto6, Jorge Guedes Campos4,5, Mamede de Carvalho6,7. 1. Department of Neuroradiology, CHLN-Hospital de Santa Maria, Lisbon, Portugal. anafilipageraldo@gmail.com. 2. Department of Radiology, Neuroradiology Unit, CHVNG/E-Centro Hospitalar Vila Nova de Gaia, Espinho, Portugal. anafilipageraldo@gmail.com. 3. Institute for Nuclear Sciences Applied to Health (ICNAS), and Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal. 4. Department of Neuroradiology, CHLN-Hospital de Santa Maria, Lisbon, Portugal. 5. Faculty of Medicine, University of Lisbon, Lisbon, Portugal. 6. Institute of Physiology, Institute of Molecular Medicine (IMM), Faculty of Medicine, University of Lisbon, Lisbon, Portugal. 7. Department of Neurosciences and Mental Health, CHLN-Hospital de Santa Maria, Lisbon, Portugal.
Abstract
PURPOSE: This paper aims to analyze the contribution of mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in the detection of microstructural abnormalities in amyotrophic lateral sclerosis (ALS) and to evaluate the degree of agreement between structural and functional changes through concomitant diffusion tensor imaging (DTI), transcranial magnetic stimulation (TMS), and clinical assessment. METHODS: Fourteen patients with ALS and 11 healthy, age- and gender-matched controls were included. All participants underwent magnetic resonance imaging including DTI. TMS was additionally performed in ALS patients. Differences in the distribution of DTI-derived measures were assessed using tract-based spatial statistical (TBSS) and volume of interest (VOI) analyses. Correlations between clinical, imaging, and neurophysiological findings were also assessed through TBSS. RESULTS: ALS patients showed a significant increase in AD and MD involving the corticospinal tract (CST) and the pre-frontal white matter in the right posterior limb of the internal capsule (p < 0.05) when compared to the control group using TBSS, confirmed by VOI analyses. VOI analyses also showed increased AD in the corpus callosum (p < 0.05) in ALS patients. Fractional anisotropy (FA) in the right CST correlated significantly with upper motor neuron (UMN) score (r = - 0.79, p < 0.05), and right abductor digiti minimi central motor conduction time was highly correlated with RD in the left posterior internal capsule (r = - 0.81, p < 0.05). No other significant correlation was found. CONCLUSION: MD, AD, and RD, besides FA, are able to further detect and characterize neurodegeneration in ALS. Furthermore, TMS and DTI appear to have a role as complementary diagnostic biomarkers of UMN dysfunction.
PURPOSE: This paper aims to analyze the contribution of mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in the detection of microstructural abnormalities in amyotrophic lateral sclerosis (ALS) and to evaluate the degree of agreement between structural and functional changes through concomitant diffusion tensor imaging (DTI), transcranial magnetic stimulation (TMS), and clinical assessment. METHODS: Fourteen patients with ALS and 11 healthy, age- and gender-matched controls were included. All participants underwent magnetic resonance imaging including DTI. TMS was additionally performed in ALSpatients. Differences in the distribution of DTI-derived measures were assessed using tract-based spatial statistical (TBSS) and volume of interest (VOI) analyses. Correlations between clinical, imaging, and neurophysiological findings were also assessed through TBSS. RESULTS:ALSpatients showed a significant increase in AD and MD involving the corticospinal tract (CST) and the pre-frontal white matter in the right posterior limb of the internal capsule (p < 0.05) when compared to the control group using TBSS, confirmed by VOI analyses. VOI analyses also showed increased AD in the corpus callosum (p < 0.05) in ALSpatients. Fractional anisotropy (FA) in the right CST correlated significantly with upper motor neuron (UMN) score (r = - 0.79, p < 0.05), and right abductor digiti minimi central motor conduction time was highly correlated with RD in the left posterior internal capsule (r = - 0.81, p < 0.05). No other significant correlation was found. CONCLUSION: MD, AD, and RD, besides FA, are able to further detect and characterize neurodegeneration in ALS. Furthermore, TMS and DTI appear to have a role as complementary diagnostic biomarkers of UMN dysfunction.
Entities:
Keywords:
Amyotrophic lateral sclerosis; Diffusion tensor imaging; Magnetic resonance imaging; Motor neuron disease; Transcranial magnetic stimulation
Authors: C M Ellis; A Simmons; D K Jones; J Bland; J M Dawson; M A Horsfield; S C Williams; P N Leigh Journal: Neurology Date: 1999-09-22 Impact factor: 9.910
Authors: Matthew S Devine; Matthew C Kiernan; Susan Heggie; Pamela A McCombe; Robert D Henderson Journal: Amyotroph Lateral Scler Frontotemporal Degener Date: 2014-05-09 Impact factor: 4.092
Authors: F Agosta; E Pagani; M Petrolini; D Caputo; M Perini; A Prelle; F Salvi; M Filippi Journal: AJNR Am J Neuroradiol Date: 2010-04-15 Impact factor: 3.825
Authors: Mamede de Carvalho; Reinhard Dengler; Andrew Eisen; John D England; Ryuji Kaji; Jun Kimura; Kerry Mills; Hiroshi Mitsumoto; Hiroyuki Nodera; Jeremy Shefner; Michael Swash Journal: Clin Neurophysiol Date: 2007-12-27 Impact factor: 3.708
Authors: Bradley R Foerster; Ben A Dwamena; Myria Petrou; Ruth C Carlos; Brian C Callaghan; Martin G Pomper Journal: Acad Radiol Date: 2012-06-28 Impact factor: 3.173
Authors: Jong Seok Bae; Michele Ferguson; Rachel Tan; Eneida Mioshi; Neil Simon; James Burrell; Steve Vucic; John R Hodges; Matthew C Kiernan; Michael Hornberger Journal: J Clin Neurol Date: 2016-02-26 Impact factor: 3.077