Economic burden of neonatal sepsis in sub-Saharan Africa.

BACKGROUND AND SIGNIFICANCE: The third Sustainable Development Goal for child health, which aims to end preventable deaths of newborns and children less than 5 years of age by 2030, cannot be met without substantial reduction of infection-specific neonatal mortality in the developing world. Neonatal infections are estimated to account for 26% of annual neonatal deaths, with mortality rates highest in sub-Saharan Africa (SSA). Reliable and comprehensive estimates of the incidence and aetiology surrounding neonatal sepsis in SSA remain incompletely available. We estimate the economic burden of neonatal sepsis in SSA.
METHODS: Data available through global health agencies and in the medical literature were used to determine population demographics in SSA, as well as to determine the incidence, disease burden, mortality and resulting disabilities associated with neonatal sepsis. The disability-adjusted life years (DALY) associated with successful treatment or prevention of neonatal sepsis in SSA for 1 year were calculated. The value of a statistical life (VSL) methodology was estimated to evaluate the economic burden of untreated neonatal sepsis in SSA.
RESULTS: We conservatively estimate that 5.29-8.73 million DALYs are lost annually in SSA due to neonatal sepsis. Corresponding VSL estimates predict an annual economic burden ranging from $10 billion to $469 billion.
CONCLUSIONS: Our results highlight and quantify the scope of the public health and economic burden posed by neonatal sepsis in SSA. We quantify the substantial potential impact of more successful treatment and prevention strategies, and we highlight the need for greater investment in strategies to characterise, diagnose, prevent and manage neonatal sepsis and its long-term sequelae in SSA.

Neonatal sepsis causes an estimated 750 000 annual deaths worldwide with mortality highest in sub-Saharan Africa (SSA).

Describing the economic burden of disease resulting from neonatal infections in SSA is key to advancing global public health policies.

Neonatal sepsis is responsible for 1.6 times the global number of childhood deaths as malaria, and over four times the number of childhood deaths caused by HIV.

Despite its disproportionate burden on childhood mortality, neonatal sepsis receives vastly less investment internationally as a public health priority compared with other major conditions.

The incidence, disease burden, mortality and resulting disabilities associated with neonatal sepsis were estimated.

The disability-adjusted life years (DALY) associated with successful treatment or prevention of neonatal sepsis in SSA and the value of a statistical life (VSL) methodology was estimated for the potential economic burden resulting from neonatal sepsis in SSA.

Estimates of 5.29–8.73 million DALYs are lost annually in SSA due to neonatal sepsis, and the corresponding VSL method predicts an annual economic burden ranging from $10 billion to $469 billion.

These results highlight and quantify the scope of the public health and economic burden posed by neonatal sepsis in SSA.

These results quantify the substantial potential impact of more successful treatment and prevention strategies, and highlight the need for greater investment in strategies to characterise, diagnose, prevent and manage neonatal sepsis and its long-term sequelae in SSA.

Introduction

The third Sustainable Development Goal for child health (United Nations 2015), which aims to end preventable deaths of newborns and children under 5 years of age by 2030, cannot be met without substantial reduction of infection-specific neonatal mortality in the developing world. Sub-Saharan Africa (SSA) bears a disproportionate burden of neonatal mortality, contributing an estimated 49.6% of under-5 deaths in 2013.1 Worldwide, neonatal infections cause an estimated 26% of under-5 deaths, with mortality rates highest in sub-Saharan Africa.2–4 Neonatal sepsis, a condition defined as bacteraemia within the first month of life accompanied by signs of systemic infection,5 results in an estimated 750 000 annual deaths worldwide.6–8 Describing the economic burden of disease resulting from neonatal infections in SSA is key to advancing global public health policies.

Worldwide neonatal deaths have decreased by over 3.6 million per year since 2000, largely due to decreases in the incidence of major conditions such as pneumonia and diarrhoea. However, neonatal sepsis remains a notable counterexample to the progress in the decline of cause-specific mortality rates.1 Neonatal sepsis is responsible for 1.6 times the global number of childhood deaths as malaria, and over four times the number of childhood deaths caused by HIV.8 Despite its disproportionate burden on childhood mortality, neonatal sepsis receives substantially less investment internationally as a public health priority compared with other major conditions.

Previous estimates, reporting a range of 380 000–2 000 000 annual cases of neonatal sepsis in sub-Saharan Africa and 270 000 annual associated deaths,3 8 highlight the substantial burden of disease. However, accurately estimating the burden of neonatal sepsis in sub-Saharan Africa is limited by uncertainty in the diagnosis and estimations of the incidence. Data detailing the aetiology, scope and interventions surrounding neonatal sepsis in the developing world are lacking. The identification and treatment of newborns with infection are particularly limited in the developing world.5 In resource-poor settings, with limited access to blood cultures and reliable laboratory testing, diagnosis of neonatal sepsis is typically based only on clinical indications.1 Most estimates of incidence are obtained from isolated community-based studies, where significant heterogeneity makes data difficult to compare.8–10 Estimates of the incidence of neonatal sepsis in community settings in the developing world can range from 5.5/1000 live births by positive blood culture to 170/1000 live births based on clinical diagnosis.10 Successful intervention in neonatal sepsis requires investment in high-quality data and reliable identification of neonatal sepsis.

The purpose of this investigation is to quantify the economic burden associated with neonatal sepsis in sub-Saharan Africa, thereby motivating investment in interventions. Using the measure of the disability-adjusted life year (DALY), we determine the years of healthy life lost and the subsequent potential economic loss that could be averted in 1 year by complete eradication of neonatal sepsis, using data from 2014.

Methods

Disability-adjusted life years

To quantify health outcomes associated with neonatal sepsis, we calculate DALYs. The DALY measures the combined burden of premature death caused by a condition and the lifelong impact of the disease.11 12 DALYs secondary to a particular condition are the sum of years of life lost due to premature mortality (YLL) and years lost to disability (YLD). YLDs are scaled by a disability weight (DW), a factor that ranges from 0 (perfect health) to 1 (death) to reflect the severity of the condition.

The calculation of DALYs can be moderated by age weighting and discounting. Age weighting accounts for the behavioural preference of a society with regard to age across a lifespan.11 13 Discounting, a standard practice in cost-benefit analysis, devalues future years of life relative to the present day. In disease management, discounting motivates investment in immediate healthcare expenditures relative to theoretical future benefits of investment in research and eradication programmes.14 Discounting allows DALYs calculated at each year to be summed and compared over a lifetime.

The most recent (2010) Global Burden of Disease and Risk Factors report did not use discounting or age weighting within the calculation of DALYs.15 16 However, in the context of cost utility analysis, which provides an economic estimate of the associated burden of disease, these features may account for important cultural realities that affect the practical evaluation of disease burden. Furthermore, these features yield conservative estimates of both disease burden and economic benefits relative to calculations that do not discount or age weight. In accordance with previous analyses of the disease burden of infant conditions in SSA,7 we employ a standard 3% discount rate and an age weighting parameter linked to life expectancy.

To evaluate both the economic burden of disease we translate between DALY and monetary value in US$. We use value of a statistical life (VSL) methodology17 18 to quantify the economic burden resulting from neonatal sepsis cases in sub-Saharan Africa over 1 year in 2014.

Categorisation of disease processes involved with neonatal sepsis

The long-term sequelae resulting from neonatal sepsis are difficult to quantify. We used secondary conditions with known incidence to approximate the burden caused by neonatal sepsis over a lifetime. We employed standard disability weights (DW) derived from the Global Burden of Disease and Risk Factors report16 and other literature to evaluate the impact of each secondary condition.

Eight conditions were examined in the breakdown of neonatal sepsis in SSA (figure 1): (1) death from sepsis; (2) long-term survival with postinfectious hydrocephalus (PIH), which could result in (3) childhood mortality or (4) survival with PIH with resulting neurological impairment; (5) long-term survival from sepsis with neurodevelopmental impairment, which could result in (6) cerebral palsy or (7) lifetime neurodevelopmental impairment without cerebral palsy; or (8) uncomplicated recovery following an acute 2-week period of neonatal sepsis.

Figure 1

Flow chart of outcomes associated with neonatal sepsis in sub-Saharan Africa (SSA) used in the calculation of disability-adjusted life years (DALY). The incidence of conditions secondary to neonatal sepsis was calculated in relation to the total annual live births in SSA.

The fraction of the neonatal mortality attributed to sepsis in SSA was multiplied against the current neonatal mortality rate (NMR) to determine the incidence of death secondary to neonatal sepsis. The case fatality rate associated with neonatal sepsis in the developing world was then used to determine the incidence of neonatal sepsis as a fraction of total annual live births (adjusted for the baseline neonatal mortality rate). Available incidence data from the literature for secondary conditions were used to determine the number of individuals in each corresponding category. Given the limited and conflicting data surrounding the epidemiology of neonatal infections in SSA, we evaluated a range of epidemiological parameters from the literature. For example, when considering the fraction of the NMR attributed to sepsis in SSA, we evaluated a range spanning the per cent NMR attributed strictly to sepsis to the per cent attributed generally to infections in the neonatal period. Table 1 lists the epidemiological parameters used for the analysis. Further discussion of the parameter choices is presented in online supplementary material.

Table 1

Epidemiological parameters used in the calculation of DALYs lost secondary to neonatal sepsis in sub-Saharan Africa for the year 2014

Epidemiological parameter	Value	Source	Population
Life expectancy	57	World Bank36	Sub-Saharan Africa
Crude birth rate	37*	World Bank36	Sub-Saharan Africa
Infant mortality	77†	World Bank36	Sub-Saharan Africa
Population	961.5 million	World Bank36	Sub-Saharan Africa
NMR	29†	World Bank36	Sub-Saharan Africa
% NMR attributable to NS	17%–29%	UN IGCME37	Sub-Saharan Africa
Case fatality rate for NS	50%	WHO 20053 38	Sub-Saharan Africa
Incidence of PIH	3–5†	Warf et al  7	Ugandan infants
Risk of cerebral palsy secondary to NS	3.2%–16.3%‡	Consensus from the literature§	International meta-analyses among low birthweight infants in low-income and middle-income countries
Risk of total neurodevelopmental impairment secondary to NS	26.4%–47.4%§	Consensus from the literature§	International meta-analyses among low birthweight infants in low-income and middle-income countries

*Value per 1000 persons.

†Value per 1000 live births.

‡Range gives 95% CI reported in the literature.

§See further discussion in online supplementary materials.

DALY, daily-adjusted life year; NMR, neonatal mortality rate; NS, neonatal sepsis; PIH, postinfectious hydrocephalus; UN IGCME, United Nations Inter-agency Group for Child Mortality Estimation.

Little data exist detailing disability outcomes that are the direct effect of neonatal sepsis in SSA. Data regarding rates of neurodevelopmental impairment and cerebral palsy following sepsis were incorporated from the literature. Hydrocephalus, a syndrome characterised by accumulation of excess cerebrospinal fluid and expansion of the cranial vault, is predominantly postinfectious following neonatal sepsis in infants in East Africa.19 20 A previous study that examined the economic burden of disease for PIH in SSA suggests a magnitude sufficient to warrant the separate breakout for PIH that we have used here.7 The incidence of PIH in Uganda has been characterised,19 and the resulting incidence of PIH in sub-Saharan Africa was estimated using the Ugandan estimates. Furthermore, Warf et al  7 characterised the mortality in children less than 5 years of age from PIH after initial survival of sepsis. These rates were also extrapolated to SSA.

Selection of VSL methodology for economic analysis

Two general strategies exist to translate between DALYs and US$: the human capital approach (HCA) and the VSL approach. The HCA was initially suggested for use with DALYs by the WHO Commission on Macroeconomics and Health.21 According to the HCA, the value of an individual to society is estimated by an individual’s earnings, or their contribution to the national economy. DALYs are directly valued by the gross national income (GNI) per capita in a country or region to obtain an estimate of the potential economic burden of DALYs averted over a lifetime.

In contrast, the VSL approach is based on empirical studies of an individual’s willingness to pay for incremental reductions of their risk of dying. VSL estimates may also be used to derive the value of a statistical life year (VSLY), which can be used to assign a monetary value to 1 DALY.

We suggest that VSL achieves a more realistic approximation of the economic burden associated with neonatal sepsis in SSA. VSL has been sanctioned for use in cost-benefit analysis by government agencies in the USA and Australia,17 22 and is gaining ground in the international community.23 Because the methodology uses empirical evidence of human behaviour, it approximates the way in which individuals actually value reductions in health risks. For a study evaluating the economic burden of disease in the developing world, where GNI per capita averages are substantially less than those in the industrialised countries, the discrepancy between willingness to pay and lifetime income is important.

Calculation of DALYs

A detailed mathematical explanation of the calculation of DALYs is provided in the online supplementary materials. To determine the DALYs averted by the potential eradication of neonatal sepsis, we determined and summed the DALYs associated with each breakout condition attributed to sepsis (figure 1). DALYs were calculated for an initial period of acute neonatal sepsis, beginning at age zero. DALY calculations for sequential conditions were calculated from the age of onset of the condition, with the minimum age being 2 weeks, to the end of the duration of the condition. For example, in the case of PIH secondary to neonatal sepsis, we applied the DW for severe acute infection (table 2) over a 2-week period. Next, for survivors of PIH secondary to sepsis, we applied the DW for moderate intellectual disability and motor delay from age 2 weeks to the life expectancy. For the condition of childhood death following PIH secondary to sepsis, years of life lost were calculated beginning at age 5. Assuming survival until age 5 provides the most conservative estimate of DALYs for this cohort, since we have figures for 5-year survival in this cohort. The World Bank-reported life expectancy for sub-Saharan Africa of 57 years of age was used as the upper limit of evaluation for DALYs.

Table 2

DWs used in the calculation of DALYs for conditions associated with neonatal sepsis in sub-Saharan Africa.

Disability weight	Value	Source
DW neonatal sepsis	0.613	Iran Burden of Disease Study24
DW moderate intellectual and motor delay	0.221 (0.141–0.314)	WHO Global Burden of Disease 201015
DW cerebral palsy (without intellectual disability)	0.170	Dutch Burden of Disease Study24 25
DW during acute meningitis (acute PIH)	0.894	Dutch Burden of Disease Study24 25

PIH is associated with preceding episodes of neonatal meningitis and cerebral ventriculitis.20 In order to quantify the damage to quality of life posed by PIH, the disability weight for neonatal meningitis was used

*Range gives 95% confidence interval reported in the literature

DALY, daily-adjusted life year; DW, disability weight; PIH, postinfectious hydrocephalus.

The DW for each condition associated with neonatal sepsis was obtained from the 2010 Global Burden of Disease and Risk Factors study and from a 2003 study of the burden of disease in Iran.15 24 25 The values used for each condition are given in table 2.

We used an annual discounting rate of 3% as suggested by Murray and Acharya.26 To account for age weighting in accordance with the VSL methodology, we used an age-weighting factor β determined by empirical evidence27 and adjusted to the life expectancy reported in sub-Saharan Africa (see online supplementary material for a more detailed description of these parameters).

For several of the epidemiological parameters (tables 2 and 3), uncertainty was reported along with a point estimate of the parameter value. We report total DALYs as a range calculated over the reported intervals for each parameter.

Evaluating the economic burden of neonatal sepsis: translation of DALYs to US$ in VSL methodology

Viscusi and Aldy presented a model to estimate the value of a statistical life in US$ in countries where formal studies have not been conducted to determine a base estimate of VSL.18 The Department of Transportation (DOT) estimates a base VSL of $9.2 million for the USA based on empirical studies.22 The VSL of a country in SSA can be determined comparatively as follows:

­

where is the value of a statistical life for sub-Saharan Africa, is the gross national income (GNI) per capita for sub-Saharan Africa, is the value of a statistical life for the USA, is the GNI per capita in the USA, and E denotes the income elasticity of VSL.28

In VSL methods, the income elasticity moderates the extrapolation of VSL estimates across countries based on differences in GNI per capita. Constant VSL (E=0) implies that citizens in a country in SSA and citizens in the USA would be willing to pay equally for an incremental decrease in risk of death or disability. However, that amount would represent a vastly larger percentage of total income for the citizens of a country in SSA than for those in the USA. If VSL varies proportionally to income (E=1), then the value of a statistical life of a person in SSA would appear lower than that of a person in the USA. If mortality risk reductions are viewed as luxuries (E>1), then it follows that a person in SSA, with higher economic constraints, would not be as willing to pay an equivalent relative amount for risk reduction, resulting in a further lowering of VSL. However, if mortality risk reductions are viewed as necessities (E<1), then equation (1) can be used to translate VSL across income differences. Viscusi and Aldy suggest an elasticity of E=0.55,18 which reflects the willingness to pay rather than actual income in the calculation of VSL for a country in sub-Saharan Africa. Hammit and Robinson28 argue, however, that the income elasticity of VSL is greater than 1.0 for poor countries, and recommend against using income elasticity values below 1. We therefore used two other scenarios (E=1, direct GNI scaling, and E=1.5, luxury GNI scaling) to provide a more complete spectrum of economic estimates.

In order to use VSL to evaluate the economic impact of DALYs associated with each condition, we calculated an age-independent annual value of a statistical life lost per year, or the VSLY, in sub-Saharan Africa and multiplied this value by the number of DALYs associated with each condition.

Results

For 2014, based on table 1, we conservatively estimate 355 500–605 750 annual cases and 177 500–302 870 annual deaths due to neonatal sepsis in SSA.

The lifelong burden of neonatal sepsis was categorised based on secondary long-term sequelae (figure 1), each with a unique disability weight (DW) according to the Global Burden of Disease and Risk Analysis report and a 2003 study conducted in Iran (table 2).15 24 25 If all cases of neonatal sepsis for 1 year had been successfully treated or prevented, a total of 5.29–8.73 million DALYs could have been averted over an average lifetime (table 3).

Table 3

Total potential DALYs averted over a lifetime, and associated economic value, given successful prevention or treatment of all cases of neonatal sepsis in sub-Saharan Africa over 1 year in 2014.

Parameter	Value
Total DALYs	5.29–8.73 million
Economic burden
E=1.5	$9.93–$16.40 billion
E=1	$58.02–$95.81 billion
E=0.55	$284.12–$469.15 billion

Value ranges reflect the ranges of reported parameter values used from the literature. The economic burden is calculated using the value of a statistical life methodology under three different assumptions of income elasticity (E=1.5, E=1, E=0.55)

DALY, daily-adjusted life year.

The annual economic implications of the potential DALYs averted by successful treatment or prevention of sepsis are substantial. The VSL approach for economic valuation of DALYs suggested a wide range of potential value from $9.3 billion (E=1.5) to $469.15 billion (E=0.55). The economic impact of each scenario is provided in table 3.

Discussion

This work quantifies the substantial disease burden posed by neonatal sepsis in SSA, and is to our knowledge the first to provide an economic estimate of the burden of this condition for the region. Our results indicate that neonatal sepsis presents a $10–$469 billion financial burden that could be alleviated through successful treatment and prevention.

Though large in scope, our results likely underestimate disease burden. Previous studies estimated 1–2 million yearly cases of neonatal sepsis in SSA.3 Recent literature provided a more conservative range of 380 000–870 000 annual cases, and 270 000 annual deaths due to neonatal sepsis for the year 2010.8 Our estimates of annual incidence and mortality secondary to neonatal sepsis in SSA provide a conservative range that overlaps these estimates. Furthermore, our estimates of the DALYs secondary to neonatal sepsis in sub-Saharan Africa are substantially lower than the estimated 11–30 million DALYs reported in the 2010 Global Burden of Disease study.16 This difference is partly due to our choice to use age weighting and discounting in our calculation of DALYs. We therefore maintain a conservative estimate of the corresponding economic impact.

The broad estimated range of the economic burden reflects different interpretations of the income elasticity between the USA and SSA. We prefer to not impose value judgements on populations regarding the value of life biased towards necessity versus luxury, but offer the full range of quantitative estimates in current use. Within this range lie the applicable values, and they reflect the enormous burden of neonatal sepsis on morbidity, mortality and economic burden.

Broadly, high-quality data are needed to make policy decisions that can help reduce neonatal mortality. Neonatal sepsis has begun to gain recognition in the international community as a major and under-represented global health crisis,5 29 but information regarding the aetiology, scope and treatment strategies remains substantially underdeveloped. Research into the complete spectrum of invasive microorganisms contributing to neonatal sepsis in sub-Saharan Africa—the neonatal septisome 30 31—is necessary both to optimise treatment and to develop rational public health strategies. Through thorough and standardised methodology and access to accurate diagnosis, the incidence of sepsis can be better understood across communities. Furthermore, to accurately evaluate the burden of sepsis, better data are needed detailing the scope, severity and duration of long-term sequelae. For example, while the burden of an acute febrile episode can be approximated over a very short (weeks) timespan by the disability weight for acute meningitis, data are lacking to estimate more accurately the subsequent impairment over a lifetime, and the effect on shortening that lifetime.

Investments in public health efforts to counter the substantial burden of neonatal sepsis are important at various population scales. We quantified the burden of neonatal sepsis at the regional level across sub-Saharan Africa, in line with the focus under the Sustainable Development Goals on reducing disparities in child survival between SSA and other world regions.32 Such regional-level analysis puts our work in context with important contemporary estimates of the burden of childhood and neonatal disease at the same scale.1 8 However, country-specific data about the incidence and outcomes of neonatal sepsis could be gained through investments at the national level across SSA. Our model could be used to quantify the country-specific burden of neonatal sepsis, informing public health policy and decision-making at the individual national scale.

Serious neonatal infections bear a substantial morbidity risk even when mortality is averted through successful treatment, and the optimal treatment for these infants is prevention. More adequate prevention poses a substantial challenge, since mounting the effort to identify regionally the most common routes of infection, and the potential role of multiorganism primary infections or sequential secondary infections, remains a substantial barrier towards rational and granular public health preventative policies. Recent evidence suggests that rainfall and climate may play a significant role in neonatal sepsis cases leading to nervous system involvement in Uganda,33 and the role that climate plays in neonatal sepsis in SSA remains to be defined.

The economic impact of neonatal mortality is connected to a more complex set of social and economic issues in a society than is reflected in our focus on individual DALY and VSL considerations. For instance, in the economic report Uganda 2040,34 the high birth rate (averaging 6.7 per woman per lifetime) is considered as a major economic burden on society. At such high birth rates, women are effectively excluded from the economy. High neonatal mortality helps drive such high birth rates. If infant mortality is decreased, the ripple effect through the society can be economically substantial.

We are mindful of the limitations associated with the VSL methodology used to evaluate the economic burden associated with neonatal sepsis.

Of the global infectious killers of children, neonatal sepsis may be the most treatable and preventable. We are cautious in this statement, because without a more comprehensive assessment of the spectrum of microorganisms and their routes of infection in the developing world, the magnitude of the challenge posed to reduce the disability, death and economic impact of this condition remains uncertain. Our findings help quantify the immense burden posed by neonatal sepsis in SSA, and stress that the achievement of international milestones in child health will require a refocusing of priorities that includes more comprehensive characterisation of neonatal sepsis to serve as a basis for more effective treatment and rational public health policy.

Limitations of the study

Our estimates were primarily limited by the quality of comprehensive and accurate information available for neonatal sepsis worldwide. The debilitating outcomes of this syndrome remain poorly characterised in the developing world. Meningitis, PIH and neurodevelopmental impairment with possible cerebral palsy were the best defined disabilities in survivors of neonatal sepsis because they are quantifiable through clinical examination. Information regarding disabilities affecting other major organ systems (kidney, lung, liver, and so on) that arise from neonatal sepsis and impair health in survivors is generally unavailable. The inclusion of accurate disability figures related to other organ systems would refine our economic burden estimates.

The use of the value of a statistical life framework for the economic valuation of the burden of neonatal sepsis in SSA carries several limitations. Notably, the use of GNI per capita as a uniform marker of individual economic potential ignores important cultural heterogeneities. Our results must therefore be interpreted with caution. To partially address the associated uncertainty in the translation of DALYs to US$, we estimated the economic burden of disease across a range of potential income elasticities, and we avoided focusing on a measure of central tendency (eg, mean).

Because we were limited by lack of available incidence data describing the sequelae of neonatal sepsis in SSA, we at times needed to employ available incidence data from other areas of the developing world. The literature describing conditions secondary to neonatal sepsis in the developing world relies heavily on compilations of isolated community studies, which limits its generalisability to SSA.5 The incidence of PIH was extrapolated to SSA from estimates of the PIH burden in Uganda,7 and the outcomes of PIH were conservatively estimated assuming all children were optimally treated.35

Despite these uncertainties, our estimates, though substantial, likely underestimate the true burden of neonatal sepsis in sub-Saharan Africa. Our estimates of the incidence, DALYs and, therefore, the economic burden attributable to neonatal sepsis are conservative with respect to current estimates from the literature.

Conclusion

Neonatal sepsis poses a massive public health burden for sub-Saharan Africa, with significant associated economic consequences. Strategic investment in characterisation of the disease aetiology, diagnosis, treatment and prevention is warranted.