Songhao Li1, Young Hyun Kim2,3, Wing Li3, Meng C Lin2,3, Clayton J Radke1. 1. Chemical and Biomolecular Engineering Department, University of California, Berkeley, Berkeley, California. 2. Vision Science Graduate Group, University of California, Berkeley, Berkeley, California. 3. Clinical Research Center, School of Optometry, University of California, Berkeley, Berkeley, California *radke@berkeley.edu.
Abstract
SIGNIFICANCE: A simple methodology is presented to quantify basal tear production with a modified Schirmer-tear test. PURPOSE: We introduce a simple clinical procedure to measure quantitative basal tear-production flowrates, QL, from a modified Schirmer-tear test (STT). METHODS: Eight healthy subjects aged at least 18 years underwent modified STTs on both eyes for two visits each. Schirmer strips were sheathed with transparent tape before insertion. Topical anesthetic minimized reflex tearing. Wetting lengths were measured every 30 s for 5 min; QL was calculated from the linear slope of wetting length versus time. Determination of QL requires mass-balance equations on the tear prism and Schirmer strip with strip imbibition kinetics obeying Darcy and Young-Laplace laws. RESULTS: Basal tear production rates varied from essentially 0 to about 2 μl/min. With some exceptions, right and left eyes showed similar tear production rates. CONCLUSIONS: By following the modified STT, QL is established with minimal additional effort over a standard Schirmer test. We predict and observe four different subtypes of imbibition kinetics depending on how short or long the time is for first appearance of the wetting front and on how fast or slow is tear production. For slow lacrimal production rates, the standard 5-min wetting length does not correlate with basal tear production.
SIGNIFICANCE: A simple methodology is presented to quantify basal tear production with a modified Schirmer-tear test. PURPOSE: We introduce a simple clinical procedure to measure quantitative basal tear-production flowrates, QL, from a modified Schirmer-tear test (STT). METHODS: Eight healthy subjects aged at least 18 years underwent modified STTs on both eyes for two visits each. Schirmer strips were sheathed with transparent tape before insertion. Topical anesthetic minimized reflex tearing. Wetting lengths were measured every 30 s for 5 min; QL was calculated from the linear slope of wetting length versus time. Determination of QL requires mass-balance equations on the tear prism and Schirmer strip with strip imbibition kinetics obeying Darcy and Young-Laplace laws. RESULTS: Basal tear production rates varied from essentially 0 to about 2 μl/min. With some exceptions, right and left eyes showed similar tear production rates. CONCLUSIONS: By following the modified STT, QL is established with minimal additional effort over a standard Schirmer test. We predict and observe four different subtypes of imbibition kinetics depending on how short or long the time is for first appearance of the wetting front and on how fast or slow is tear production. For slow lacrimal production rates, the standard 5-min wetting length does not correlate with basal tear production.
Authors: Majid Moshirfar; Harry Y Liu; David B Rosen; Madeline B Heiland; Masoud Mirghorbani; Yasmyne C Ronquillo; Phillip C Hoopes Journal: Med Hypothesis Discov Innov Ophthalmol Date: 2019