| Literature DB >> 29561022 |
Bo Fan1, Wenxin Dong1, Tianyi Chen1, Jianlin Chu2, Bingfang He3.
Abstract
The 62nd residue of glycosyltransferase UGTBL1 was identified as a "hotspot" for glycosylation at 3-OH of resveratrol. Via semi-rational design including structure-guided alanine scanning and saturation mutations, the mutation I62G significantly switched the regioselectivity from 4'-OH to 3-OH of resveratrol and mainly produced polydatin (87.7%), a therapeutic natural product.Entities:
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Year: 2018 PMID： 29561022 DOI： 10.1039/C8OB00376A
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876