| Literature DB >> 29559747 |
Honghong Zhou1,2, Yongshuo Liu1, Rui Zhu1, Fang Ding1, Xiufeng Cao3, Dongxin Lin1,2, Zhihua Liu4.
Abstract
Snail is a key regulator of epithelial-mesenchymal transition (EMT) and plays an important role in tumor progression and metastasis. Snail is rapidly degraded in the cells and its protein level is critically controlled. Although several E3 ligases regulating Snail degradation have been defined, the deubiquitinases (DUBs) responsible for Snail deubiquitination are less studied. We identified ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) as a DUB that stabilizes Snail through preventing its ubiquitination and proteasomal degradation. Functionally, OTUB1 facilitates metastasis of esophageal squamous cell carcinoma (ESCC) through promoting Snail protein stability. Moreover, OTUB1 is highly expressed in ESCC and higher expression of OTUB1 predicts poor prognosis. These findings suggest that OTUB1 is an essential regulator of Snail and plays a critical role in facilitating esophageal cancer progression.Entities:
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Year: 2018 PMID： 29559747 DOI： 10.1038/s41388-018-0224-1
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867