| Literature DB >> 29559739 |
Shomi Oka1,2, Takashi Higuchi1, Hiroshi Furukawa3,4, Minoru Nakamura5, Atsumasa Komori6,7, Seigo Abiru7, Shinya Nagaoka7, Satoru Hashimoto7, Atsushi Naganuma7, Noriaki Naeshiro7, Kaname Yoshizawa7, Masaaki Shimada7, Hideo Nishimura7, Minoru Tomizawa7, Masahiro Kikuchi7, Fujio Makita7, Haruhiro Yamashita7, Keisuke Ario7, Hiroshi Yatsuhashi6,7, Shigeto Tohma2, Aya Kawasaki1, Naoyuki Tsuchiya1, Kiyoshi Migita6,7,8.
Abstract
Several studies reported that autoimmune diseases share a number of susceptibility genes. Of these genes, a SNP rs7708392 in TNIP1 was reported to be associated with systemic lupus erythematosus (SLE). Autoimmune hepatitis (AIH), a rare chronic progressive liver disease, shares some clinical features with SLE. Therefore, we investigated whether the SNP is associated with Japanese AIH. An association study of rs7708392 was conducted in 343 Japanese AIH patients and 828 controls. We found that rs7708392 is associated with AIH (P = 0.0236, odds ratio (OR) 1.26, 95% confidence interval (CI): 1.03-1.54), under the allele model for C allele. Significant differences of clinical characteristics of the AIH patients with or without G allele of rs7708392 were not detected. Of interest, the association was stronger in AIH without HLA-DRB1*04:05 allele (P = 0.0063, Q = 0.0127, OR 1.48, 95% CI: 1.12-1.96), though the association was not detected in AIH with DRB1*04:05. The C allele of rs7708392 was associated with AIH, especially AIH without DRB1*04:05, an already established risk factor.Entities:
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Year: 2018 PMID： 29559739 DOI： 10.1038/s10038-018-0440-0
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172