OBJECTIVE: To investigate associations of interleukin-31 (IL-31) and pruritus in atopic dermatitis (AD) with Meta-analysis. Methods: Materials were extracted from the citations listed in the following databases: PubMed, Science Direct, Web of Science and Cochrane. Key search terms included: atopic dermatitis, pruritus, and IL-31. The Meta-analysis was used to analyze the correlation between pruritws in AD and IL-31 expression level. Results: The Meta-analysis showed that serum IL-31 levels were higher in AD patients than those in the healthy controls. The levels of IL-31 were higher in severe AD patients than those in the mild and moderate AD patients. Moreover, a positive correlation between serum IL-31 levels and severity of pruritus was identified. Conclusion: Increased serum levels of IL-31 generally exist in the AD patients, and it may accelerate the pruritus in the AD patients.
OBJECTIVE: To investigate associations of interleukin-31 (IL-31) and pruritus in atopic dermatitis (AD) with Meta-analysis. Methods: Materials were extracted from the citations listed in the following databases: PubMed, Science Direct, Web of Science and Cochrane. Key search terms included: atopic dermatitis, pruritus, and IL-31. The Meta-analysis was used to analyze the correlation between pruritws in AD and IL-31 expression level. Results: The Meta-analysis showed that serum IL-31 levels were higher in ADpatients than those in the healthy controls. The levels of IL-31 were higher in severe ADpatients than those in the mild and moderate ADpatients. Moreover, a positive correlation between serum IL-31 levels and severity of pruritus was identified. Conclusion: Increased serum levels of IL-31 generally exist in the ADpatients, and it may accelerate the pruritus in the ADpatients.
Authors: May El Hachem; Giuseppe Di Mauro; Roberta Rotunno; Simona Giancristoforo; Cristiana De Ranieri; Carla Maria Carlevaris; Maria Carmen Verga; Iride Dello Iacono Journal: Ital J Pediatr Date: 2020-01-30 Impact factor: 2.638