Nazli Namazi1, Bagher Larijani2, Mohammad Hossein Ayati3, Mohammad Abdollahi4. 1. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: nazli.namazi@yahoo.com. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: larijanib@tums.ac.ir. 3. School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mh-ayati@tums.ac.ir. 4. Department of Toxicology and Pharmacology Faculty of Pharmacy, Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mohammad.abdollahi@utoronto.ca.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Nigella sativa L. (N.sativa) is a traditional herbal medicine that has been used for centuries to treat rheumatoid arthritis, diabetes, asthma, and other metabolic disorders. Recently, anti-obesity characteristics of N.sativa have been indicated. AIM OF THE STUDY: The effects of N. sativa as a complementary therapy in obesity management remains controversial. We aimed to perform a meta-analysis on the effects of supplementation with N. sativa on some anthropometric indices in adult subjects. MATERIALS AND METHODS: We searched PubMed/Medline, Cochrane Library, ISI Web of Science, and Scopus databases until June 2017 to identify relevant placebo-controlled clinical trials. Data was reported as weighted mean differences and standard deviations to show the magnitude of effects for N. sativa on body weight, body mass index (BMI) and waist circumference (WC). RESULTS: Findings of 11 studies revealed that N. sativa supplement reduced body weight (-2.11 kg, 95% CI: -3.61, -0.61, I2:72.4%), BMI (-1.16 kg/m2; 95%CI: -1.81, -0.51; I2: 40.1%) and WC (-3.52 cm, 95%CI: -4.10, -2.92, I2 =0%) significantly compared to placebo groups. CONCLUSION: Supplementation with N. sativa exerts a moderate effect on reduction in body weight, BMI and WC. However, due to the high heterogeneity for body weight and limited high quality studies, the findings should be declared by caution. No serious side effects were also reported following N. sativa supplementation. Further studies are needed to clarify the effects of N. sativa on other anthropometric indices.
ETHNOPHARMACOLOGICAL RELEVANCE: Nigella sativa L. (N.sativa) is a traditional herbal medicine that has been used for centuries to treat rheumatoid arthritis, diabetes, asthma, and other metabolic disorders. Recently, anti-obesity characteristics of N.sativa have been indicated. AIM OF THE STUDY: The effects of N. sativa as a complementary therapy in obesity management remains controversial. We aimed to perform a meta-analysis on the effects of supplementation with N. sativa on some anthropometric indices in adult subjects. MATERIALS AND METHODS: We searched PubMed/Medline, Cochrane Library, ISI Web of Science, and Scopus databases until June 2017 to identify relevant placebo-controlled clinical trials. Data was reported as weighted mean differences and standard deviations to show the magnitude of effects for N. sativa on body weight, body mass index (BMI) and waist circumference (WC). RESULTS: Findings of 11 studies revealed that N. sativa supplement reduced body weight (-2.11 kg, 95% CI: -3.61, -0.61, I2:72.4%), BMI (-1.16 kg/m2; 95%CI: -1.81, -0.51; I2: 40.1%) and WC (-3.52 cm, 95%CI: -4.10, -2.92, I2 =0%) significantly compared to placebo groups. CONCLUSION: Supplementation with N. sativa exerts a moderate effect on reduction in body weight, BMI and WC. However, due to the high heterogeneity for body weight and limited high quality studies, the findings should be declared by caution. No serious side effects were also reported following N. sativa supplementation. Further studies are needed to clarify the effects of N. sativa on other anthropometric indices.
Authors: Shabir Ahmad Mir; Ahmad Firoz; Mohammed Alaidarous; Bader Alshehri; Abdul Aziz Bin Dukhyil; Saeed Banawas; Suliman A Alsagaby; Wael Alturaiki; Gulzar Ahmad Bhat; Faizan Kashoo; Ahmad M Abdel-Hadi Journal: Saudi J Biol Sci Date: 2021-09-08 Impact factor: 4.219
Authors: Eulla Keimili Fernandes Ferreira Cavalheiro; Ana Beatriz Costa; Daniéle Hendler Salla; Mariella Reinol da Silva; Talita Farias Mendes; Larissa Espindola da Silva; Cristini da Rosa Turatti; Rafael Mariano de Bitencourt; Gislaine Tezza Rezin Journal: Cannabis Cannabinoid Res Date: 2021-07-09