Ivan Martinka1, Miriam Fulova2, Margita Spalekova2, Peter Spalek1. 1. Centre for Neuromuscular Diseases, Department of Neurology, University Hospital Bratislava, Ruzinov, Slovakia. 2. Institute of Epidemiology, Medical Faculty, Comenius University, Bratislava, Slovakia.
Abstract
PURPOSE: The objective of the study was to evaluate changes of epidemiological parameters in patients with myasthenia gravis (MG) in Slovakia during the period 1977-2015. METHODS: Data from medical records of MG patients registered in Slovakia were analyzed. Epidemiological rates (incidence, prevalence, mortality) were assessed for several periods to identify changes and drifts over the period of study. RESULTS: Out of 2,074 patients, 892 were males (43.0%) and 1,193 were females (57.0%). The thymoma associated MG (TAMG) was diagnosed in 123 patients (5.9%). The mean age at onset shifted from 35.8 years in 1977-1989 to 60.0 years in -2010-2015. The crude incidence increased from 0.36/100,000 in 1977-1989 to 1.74/100,000 in 2010-2015. The average annual incidence of TAMG was 0.05/100,000. Maximum increase of MG incidence was registered among the elderly (≥50 years), particularly in the group of patients in the age range 70-79 years (0.34/100,000 in 1977-1989→7.10/100,000 in 2010-2015) and 80-89 years (0.00/100,000 in 1977-1989→5.31/100,000 in 2010-2015). The crude MG prevalence on December 31, 2015 was 24.75/100,000. The average MG mortality was 0.27/100,000. CONCLUSION: The age at onset and incidence increased significantly over the study period due to marked increase of MG incidence in elderly, particularly over 70 years. Possible reasons for this trend are discussed.
PURPOSE: The objective of the study was to evaluate changes of epidemiological parameters in patients with myasthenia gravis (MG) in Slovakia during the period 1977-2015. METHODS: Data from medical records of MG patients registered in Slovakia were analyzed. Epidemiological rates (incidence, prevalence, mortality) were assessed for several periods to identify changes and drifts over the period of study. RESULTS: Out of 2,074 patients, 892 were males (43.0%) and 1,193 were females (57.0%). The thymoma associated MG (TAMG) was diagnosed in 123 patients (5.9%). The mean age at onset shifted from 35.8 years in 1977-1989 to 60.0 years in -2010-2015. The crude incidence increased from 0.36/100,000 in 1977-1989 to 1.74/100,000 in 2010-2015. The average annual incidence of TAMG was 0.05/100,000. Maximum increase of MG incidence was registered among the elderly (≥50 years), particularly in the group of patients in the age range 70-79 years (0.34/100,000 in 1977-1989→7.10/100,000 in 2010-2015) and 80-89 years (0.00/100,000 in 1977-1989→5.31/100,000 in 2010-2015). The crude MG prevalence on December 31, 2015 was 24.75/100,000. The average MG mortality was 0.27/100,000. CONCLUSION: The age at onset and incidence increased significantly over the study period due to marked increase of MG incidence in elderly, particularly over 70 years. Possible reasons for this trend are discussed.
Authors: Alberto Vogrig; Gian Luigi Gigli; Samantha Segatti; Elisa Corazza; Alessandro Marini; Andrea Bernardini; Francesca Valent; Martina Fabris; Francesco Curcio; Francesco Brigo; Donatella Iacono; Paolo Passadore; Michele Rana; Jérôme Honnorat; Mariarosaria Valente Journal: J Neurol Date: 2019-09-24 Impact factor: 4.849