Michael Windle1, Joshua C Gray2, Karlo Mankit Lei3, Allen W Barton3, Gene Brody3, Steven R H Beach3, Adrianna Galván4, James MacKillop5, Uraina S Clark6, Lawrence H Sweet2. 1. Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, United States. Electronic address: mwindle@emory.edu. 2. Department of Psychology, University of Georgia, Athens, United States. 3. Center for Family Research, University of Georgia, Athens, United States. 4. Department of Psychology, University of California, Los Angeles, United States. 5. Peter Boris Centre for Addictions Research, McMaster University, Hamilton, Ontario, Canada. 6. Mt. Sinai Hospital, New York, United States.
Abstract
INTRODUCTION: This study evaluated an age sensitive model of substance use across adolescence to determine if substance use was associated with smaller volumes for an earlier developing brain region, the amygdala, a later developing region, the inferior frontal gyrus, and the ventral striatum. METHOD: Participants (N = 110) were African American young adults who were members of a longitudinal cohort across childhood and adolescence. Measures of substance use were collected across early (ages 12-15 yrs.), middle (ages 16-18 yrs.), and later (ages 19-21 yrs.) adolescence; then, at age 25, a representative subset of the sample completed magnetic resonance imaging (MRI) that assessed regional brain volumes. RESULTS: Higher levels of substance use during early adolescence, but not middle or later adolescence, were significantly associated with smaller amygdalar volume in young adulthood. Higher levels of substance use during middle adolescence, but not early or later adolescence, were significantly associated with smaller pars opercularis volume. Substance use was not associated with the pars triangularis or ventral striatum. CONCLUSION: These findings support age sensitive associations between substance use and smaller gray matter volumes at age 25 and are consistent with literature supporting the differential nature of substance use and brain maturation across adolescence and into young adulthood.
INTRODUCTION: This study evaluated an age sensitive model of substance use across adolescence to determine if substance use was associated with smaller volumes for an earlier developing brain region, the amygdala, a later developing region, the inferior frontal gyrus, and the ventral striatum. METHOD:Participants (N = 110) were African American young adults who were members of a longitudinal cohort across childhood and adolescence. Measures of substance use were collected across early (ages 12-15 yrs.), middle (ages 16-18 yrs.), and later (ages 19-21 yrs.) adolescence; then, at age 25, a representative subset of the sample completed magnetic resonance imaging (MRI) that assessed regional brain volumes. RESULTS: Higher levels of substance use during early adolescence, but not middle or later adolescence, were significantly associated with smaller amygdalar volume in young adulthood. Higher levels of substance use during middle adolescence, but not early or later adolescence, were significantly associated with smaller pars opercularis volume. Substance use was not associated with the pars triangularis or ventral striatum. CONCLUSION: These findings support age sensitive associations between substance use and smaller gray matter volumes at age 25 and are consistent with literature supporting the differential nature of substance use and brain maturation across adolescence and into young adulthood.
Authors: J N Giedd; J Blumenthal; N O Jeffries; F X Castellanos; H Liu; A Zijdenbos; T Paus; A C Evans; J L Rapoport Journal: Nat Neurosci Date: 1999-10 Impact factor: 24.884
Authors: Bruce Fischl; David H Salat; Evelina Busa; Marilyn Albert; Megan Dieterich; Christian Haselgrove; Andre van der Kouwe; Ron Killiany; David Kennedy; Shuna Klaveness; Albert Montillo; Nikos Makris; Bruce Rosen; Anders M Dale Journal: Neuron Date: 2002-01-31 Impact factor: 17.173
Authors: Gene H Brody; Tianyi Yu; Yi-fu Chen; Steven M Kogan; Gary W Evans; Steven R H Beach; Michael Windle; Ronald L Simons; Meg Gerrard; Frederick X Gibbons; Robert A Philibert Journal: Dev Psychol Date: 2012-06-18
Authors: Ryan L Muetzel; Laura M E Blanken; Jan van der Ende; Hanan El Marroun; Philip Shaw; Gustavo Sudre; Aad van der Lugt; Vincent W V Jaddoe; Frank C Verhulst; Henning Tiemeier; Tonya White Journal: Am J Psychiatry Date: 2017-08-18 Impact factor: 18.112
Authors: Andrea L Gold; Margaret A Sheridan; Matthew Peverill; Daniel S Busso; Hilary K Lambert; Sonia Alves; Daniel S Pine; Katie A McLaughlin Journal: J Child Psychol Psychiatry Date: 2016-10 Impact factor: 8.982
Authors: Lindsay M Squeglia; Susan F Tapert; Edith V Sullivan; Joanna Jacobus; M J Meloy; Torsten Rohlfing; Adolf Pfefferbaum Journal: Am J Psychiatry Date: 2015-05-18 Impact factor: 18.112
Authors: Christopher D Chambers; Mark A Bellgrove; Mark G Stokes; Tracy R Henderson; Hugh Garavan; Ian H Robertson; Adam P Morris; Jason B Mattingley Journal: J Cogn Neurosci Date: 2006-03 Impact factor: 3.225
Authors: David A A Baranger; Catherine H Demers; Nourhan M Elsayed; Annchen R Knodt; Spenser R Radtke; Aline Desmarais; Lauren R Few; Arpana Agrawal; Andrew C Heath; Deanna M Barch; Lindsay M Squeglia; Douglas E Williamson; Ahmad R Hariri; Ryan Bogdan Journal: Biol Psychiatry Date: 2019-09-13 Impact factor: 13.382
Authors: Mitchell D Wong; Karen Hunter Quartz; Marisa Saunders; Ben P L Meza; Saltanat Childress; Teresa E Seeman; Rebecca N Dudovitz Journal: Pediatrics Date: 2022-05-01 Impact factor: 9.703