Literature DB >> 2955848

Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra.

R B Innis, G K Aghajanian.   

Abstract

Rat substantia nigra was injected with 1 microgram of purified pertussis toxin, a substance which inactivates the inhibitory guanine nucleotide regulatory unit of adenylate cyclase. In comparison to saline-injected animals, the pertussis toxin-treated animals showed almost no inhibition of dopaminergic neurons in response to dopamine applied iontophoretically or the dopamine agonist (-)-apomorphine given intravenously. These results provide evidence that a guanine nucleotide regulatory protein is involved as a transducer in mediating the physiological actions of dopamine autoreceptors.

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Year:  1987        PMID： 2955848     DOI： 10.1016/0006-8993(87)90690-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  18 in total

1.  Changes in the acoustic startle response and prepulse inhibition of acoustic startle in rats after local injection of pertussis toxin into the ventral tegmental area.

Authors:  J Zhang; J A Engel; S Hjorth; L Svensson
Journal:  Psychopharmacology (Berl)       Date:  1995-05       Impact factor: 4.530

Review 2.  Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism.

Authors:  A Destexhe; Z F Mainen; T J Sejnowski
Journal:  J Comput Neurosci       Date:  1994-08       Impact factor: 1.621

3.  Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra.

Authors:  A Inanobe; Y Yoshimoto; Y Horio; K I Morishige; H Hibino; S Matsumoto; Y Tokunaga; T Maeda; Y Hata; Y Takai; Y Kurachi
Journal:  J Neurosci       Date:  1999-02-01       Impact factor: 6.167

Review 4.  Somatodendritic dopamine release: recent mechanistic insights.

Authors:  Margaret E Rice; Jyoti C Patel
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-07-05       Impact factor: 6.237

5.  Spontaneous and drug-stimulated locomotor activity after the administration of pertussis toxin into the ventral tegmental area.

Authors:  S Narayanan; L Wallace; N Uretsky
Journal:  J Psychiatry Neurosci       Date:  1996-05       Impact factor: 6.186

6.  Accelerated maternal responding following intra-VTA pertussis toxin treatment.

Authors:  John J Byrnes; Erin D Gleason; Matthew K Schoen; Mathew T Schoen; Dennis F Lovelock; Lindsay M Carini; Elizabeth M Byrnes; Robert S Bridges
Journal:  Behav Brain Res       Date:  2011-05-06       Impact factor: 3.332

Review 7.  Twelfth Gaddum memorial lecture. Drug receptors and the inhibition of nerve cells.

Authors:  R A North
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

8.  Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.

Authors:  Maxime Cazorla; Mariya Shegda; Bhavani Ramesh; Neil L Harrison; Christoph Kellendonk
Journal:  J Neurosci       Date:  2012-02-15       Impact factor: 6.167

9.  Voltage- and time-dependent inhibition of neuronal calcium channels by a GTP-binding protein in a mammalian cell line.

Authors:  H Kasai
Journal:  J Physiol       Date:  1992-03       Impact factor: 5.182

10.  Brain-derived neurotrophic factor increases the electrical activity of pars compacta dopamine neurons in vivo.

Authors:  R Y Shen; C A Altar; L A Chiodo
Journal:  Proc Natl Acad Sci U S A       Date:  1994-09-13       Impact factor: 11.205
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