Literature DB >> 2955843

The effect of GR38032F, novel 5-HT3-receptor antagonist on gastric emptying in the guinea-pig.

B Costall, S J Gunning, R J Naylor, M B Tyers.   

Abstract

The effects of GR38032F a novel, selective and potent 5-hydroxytryptamine (5-HT3)-receptor antagonist on gastric emptying in the guinea-pig were investigated and compared to those of metoclopramide and haloperidol. Both GR38032F and metoclopramide increased gastric emptying in a dose-dependent manner. In contrast, haloperidol was ineffective. GR38032F was about 200 times more potent than metoclopramide in enhancing gastric emptying over the 2 h period studied.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2955843      PMCID： PMC1853517          DOI： 10.1111/j.1476-5381.1987.tb10280.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  3 in total

1.  5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205-930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in-vivo.

Authors:  K H Buchheit; B Costall; G Engel; S J Gunning; R J Naylor; B P Richardson
Journal:  J Pharm Pharmacol       Date:  1985-09       Impact factor: 3.765

2.  Interaction of levodopa and metoclopramide on gastric emptying.

Authors:  D M Berkowitz; R W McCallum
Journal:  Clin Pharmacol Ther       Date:  1980-03       Impact factor: 6.875

Review 3.  Metoclopramide. An updated review of its pharmacological properties and clinical use.

Authors:  R A Harrington; C W Hamilton; R N Brogden; J A Linkewich; J A Romankiewicz; R C Heel
Journal:  Drugs       Date:  1983-05       Impact factor: 9.546
  3 in total
  16 in total

Review 1.  Physiology and pathophysiology of colonic motor activity (1).

Authors:  S K Sarna
Journal:  Dig Dis Sci       Date:  1991-06       Impact factor: 3.199

2.  The 5HT3 antagonist GR38032F is highly toxic in DBA/2 mice.

Authors:  C A Hendrie
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

3.  Evidence that blockade of post-synaptic 5-HT1 receptors elicits feeding in satiated rats.

Authors:  C T Dourish; M L Clark; A Fletcher; S D Iversen
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

Review 4.  New developments in the treatment of functional dyspepsia.

Authors:  Vincenzo Stanghellini; Fabrizio De Ponti; Roberto De Giorgio; Giovanni Barbara; Cesare Tosetti; Roberto Corinaldesi
Journal:  Drugs       Date:  2003       Impact factor: 9.546

5.  Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors.

Authors:  A Butler; J M Hill; S J Ireland; C C Jordan; M B Tyers
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739

6.  Effect of ICS 205-930 (a specific 5-HT3 receptor antagonist) on gastric emptying of a solid meal in normal subjects.

Authors:  L M Akkermans; A Vos; A Hoekstra; J M Roelofs; M Horowitz
Journal:  Gut       Date:  1988-09       Impact factor: 23.059

7.  Evidence that the unilateral activation of 5-HT1D receptors in the substantia nigra of the guinea-pig elicits contralateral rotation.

Authors:  G A Higgins; C C Jordan; M Skingle
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

8.  Regionally selective cholinergic stimulation by BRL 24924 in the human isolated gut.

Authors:  T A Burke; G J Sanger
Journal:  Br J Clin Pharmacol       Date:  1988-09       Impact factor: 4.335

9.  Gastroprokinetic properties of the benzimidazolone derivative BIMU 1, an agonist at 5-hydroxytryptamine4 and antagonist at 5-hydroxytryptamine3 receptors.

Authors:  C A Rizzi; A Sagrada; A Schiavone; P Schiantarelli; R Cesana; G B Schiavi; H Ladinsky; A Donetti
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-04       Impact factor: 3.000

10.  Effects of ondansetron on gastric tone and motility changes induced by a prolonged intraduodenal infusion of nutrients. Results of a placebo-controlled study.

Authors:  Guillaume Savoye; Maud Brung-Lefebvre; Mickael Bouin; Céline Maillot; Philippe Denis; Philippe Ducrotté
Journal:  Dig Dis Sci       Date:  2007-03-28       Impact factor: 3.199
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.