Fast Normal Mode Computations of Capsid Dynamics Inspired by Resonance.

Increasingly more and larger structural complexes are being determined 
 experimentally. The sizes of these systems pose a formidable computational challenge 
 to the study of their vibrational dynamics by normal mode analysis. To overcome this challenge, this work presents a novel resonance-inspired approach. Tests on large shell structures 
 of protein capsids demonstrate there is a strong
 resonance between the vibrations of a whole capsid and those of individual capsomeres. 
 We then show how this resonance can be taken advantage of to significantly speed up normal 
 mode computations.