Jennifer H Walsh1,2, Carolyn Visser3, Kathleen Maddison3,4, Chrianna Bharat5,6, David R Hillman3,4, Peter R Eastwood3,4. 1. Centre for Sleep Science, School of Human Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia, 6009, Australia. Jennifer.Walsh@health.wa.gov.au. 2. Department of Pulmonary Physiology & Sleep Medicine, Sir Charles Gairdner Hospital, West Australian Sleep Disorders Research Institute, Internal Mailbox 201, QEII Medical Centre, Hospital Avenue, Nedlands, Western Australia, 6009, Australia. Jennifer.Walsh@health.wa.gov.au. 3. Centre for Sleep Science, School of Human Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia, 6009, Australia. 4. Department of Pulmonary Physiology & Sleep Medicine, Sir Charles Gairdner Hospital, West Australian Sleep Disorders Research Institute, Internal Mailbox 201, QEII Medical Centre, Hospital Avenue, Nedlands, Western Australia, 6009, Australia. 5. Centre for Applied Statistics, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia, 6009, Australia. 6. National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia.
Abstract
PURPOSE: To determine the effect of temazepam on assessment of the severity of obstructive sleep apnea (OSA) by polysomnography (PSG). METHODS: Analysis of diagnostic laboratory-PSG studies was performed in OSA patients who were administered temazepam (10 mg) to facilitate sleep ("temazepam group", n = 73) and in OSA patients (matched for age, gender, body mass index and study date) in whom temazepam was not administered ("control group", n = 73). Sleep- and respiratory-related variables were compared between the groups for the (i) first 3 h of study following temazepam in the temazepam group (when peak blood concentration is expected) or following lights out in the control group, and (ii) entire study duration. RESULTS: Within the first 3 h, no differences in sleep-related variables were observed between the groups. Over the entire study duration, the temazepam group had a reduced total sleep time compared to the control group, likely due to the overnight sleep difficulties that led to its use. Whether measured during the first 3 h of study or over the entire study duration, no significant differences were detected between the groups for any respiratory-related variable, including apnea hypopnea index, arousal index, oxygen desaturation, apnea index, hypopnea index, and event duration. When patients were considered in terms of OSA severity, decreased arousal index was noted in the temazepam group over the entire study duration, but only in those with severe OSA. CONCLUSION: Oral administration of 10 mg of temazepam during the course of PSG does not systematically affect assessment of the severity of OSA by PSG.
PURPOSE: To determine the effect of temazepam on assessment of the severity of obstructive sleep apnea (OSA) by polysomnography (PSG). METHODS: Analysis of diagnostic laboratory-PSG studies was performed in OSA patients who were administered temazepam (10 mg) to facilitate sleep ("temazepam group", n = 73) and in OSA patients (matched for age, gender, body mass index and study date) in whom temazepam was not administered ("control group", n = 73). Sleep- and respiratory-related variables were compared between the groups for the (i) first 3 h of study following temazepam in the temazepam group (when peak blood concentration is expected) or following lights out in the control group, and (ii) entire study duration. RESULTS: Within the first 3 h, no differences in sleep-related variables were observed between the groups. Over the entire study duration, the temazepam group had a reduced total sleep time compared to the control group, likely due to the overnight sleep difficulties that led to its use. Whether measured during the first 3 h of study or over the entire study duration, no significant differences were detected between the groups for any respiratory-related variable, including apnea hypopnea index, arousal index, oxygen desaturation, apnea index, hypopnea index, and event duration. When patients were considered in terms of OSA severity, decreased arousal index was noted in the temazepam group over the entire study duration, but only in those with severe OSA. CONCLUSION: Oral administration of 10 mg of temazepam during the course of PSG does not systematically affect assessment of the severity of OSA by PSG.
Authors: Jeremy S L Ong; Gabby Touyz; Sue Tanner; David R Hillman; Peter R Eastwood; Jennifer H Walsh Journal: J Sleep Res Date: 2011-05-09 Impact factor: 3.981
Authors: David Wang; Nathaniel S Marshall; James Duffin; Brendon J Yee; Keith K Wong; Nargis Noori; Susanna S W Ng; Ronald R Grunstein Journal: J Sleep Res Date: 2011-06-14 Impact factor: 3.981