Xiaoting Sun1, Lili Yang2, Jiexue Pan1, Haiyan Yang1, Yanting Wu3, Zimiao Chen4, Xia Chen5, Liangshan Mu6. 1. Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China. 2. Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China. 3. Wenzhou Medical University, 325000, Wenzhou, People's Republic of China. 4. Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China. 5. Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China. chuangchi@163.com. 6. Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, People's Republic of China. liangshanmu@hotmail.com.
Abstract
PURPOSE: Epidemiological studies had demonstrated that early age at menarche increased the risk of type 2 diabetes (T2DM), and gestational diabetes mellitus (GDM) shares many risk factors and features with T2DM. Thus, age at menarche may be a potential factor in the development of GDM. The aim of this study was to assess the association between age at menarche and the risk of gestational diabetes mellitus. METHODS: The databases of PubMed, Embase, Web of Science and Cochrane Library were searched up to June 2017. RESULTS: A total of 50,535 participants from five individual studies were included in the meta-analyses to evaluate the risk of GDM. Meta-analysis showed that women with menarche at an early age (≤11 years) had a higher GDM risk than those with menarche at age ≥12 years. (OR = 1.45, 95% CI = 1.26-1.68; P < .00001) There was low heterogeneity among the studies (Q = 6.4; P = 0.17; I2 = 38). CONCLUSIONS: This meta-analysis demonstrated that earlier menarche was strongly associated with an increased risk of GDM. A history of early age at menarche may help identify women at high risk of GDM and allow the implementation for the strategy of early prevention.
PURPOSE: Epidemiological studies had demonstrated that early age at menarche increased the risk of type 2 diabetes (T2DM), and gestational diabetes mellitus (GDM) shares many risk factors and features with T2DM. Thus, age at menarche may be a potential factor in the development of GDM. The aim of this study was to assess the association between age at menarche and the risk of gestational diabetes mellitus. METHODS: The databases of PubMed, Embase, Web of Science and Cochrane Library were searched up to June 2017. RESULTS: A total of 50,535 participants from five individual studies were included in the meta-analyses to evaluate the risk of GDM. Meta-analysis showed that women with menarche at an early age (≤11 years) had a higher GDM risk than those with menarche at age ≥12 years. (OR = 1.45, 95% CI = 1.26-1.68; P < .00001) There was low heterogeneity among the studies (Q = 6.4; P = 0.17; I2 = 38). CONCLUSIONS: This meta-analysis demonstrated that earlier menarche was strongly associated with an increased risk of GDM. A history of early age at menarche may help identify women at high risk of GDM and allow the implementation for the strategy of early prevention.
Entities:
Keywords:
Age at menarche; Gestational diabetes mellitus; Menarche
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