Mahmoud A Alomari1, Nihaya A Al-Sheyab2, Omar F Khabour3, Karem H Alzoubi4. 1. Division of Physical Therapy, Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan. Electronic address: Alomari@just.edu.jo. 2. Faculty of Nursing, Maternal and Child Health Department, Jordan University of Science and Technology, Irbid, Jordan. Electronic address: nasheyab@just.edu.jo. 3. Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Jordan. Electronic address: khabour@just.edu.jo. 4. Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. Electronic address: KHAlzoubi@just.edu.jo.
Abstract
BACKGROUND: Brain-derived neutrophic factor (BDNF) and tobacco consumption can affect many body functions and health. However, the relationship of BDNF with waterpipe (Wp) smoking is unknown. Therefore, the current study examined the relationship between Wp smoking and BDNF in adolescents. METHODS: Self-reported tobacco consumption and serum BDNF were determined in 195 waterpipe and 288 nonsmokers in 7th-10th grade students. RESULTS: Stepwise regression that included Wp smoking, gender, BMI, and location, showed that only Wp smoking (p < 0.0001) and gender (p < 0.0001) were related to serum BDNF. In addition, the ANCOVA found a main effect for Wp smoking (p < 0.0001) and gender (p < 0.0001) with lower BDNF in males smoking waterpipe. DISCUSSION: BDNF was diminished in adolescent Wp smokers, which might predispose adolescents for systematic adverse health and behavioral alterations. These results extend the negative health risks associated with cigarette smoking to that of water-pipe tobacco smoking.
BACKGROUND: Brain-derived neutrophic factor (BDNF) and tobacco consumption can affect many body functions and health. However, the relationship of BDNF with waterpipe (Wp) smoking is unknown. Therefore, the current study examined the relationship between Wp smoking and BDNF in adolescents. METHODS: Self-reported tobacco consumption and serum BDNF were determined in 195 waterpipe and 288 nonsmokers in 7th-10th grade students. RESULTS: Stepwise regression that included Wp smoking, gender, BMI, and location, showed that only Wp smoking (p < 0.0001) and gender (p < 0.0001) were related to serum BDNF. In addition, the ANCOVA found a main effect for Wp smoking (p < 0.0001) and gender (p < 0.0001) with lower BDNF in males smoking waterpipe. DISCUSSION: BDNF was diminished in adolescent Wp smokers, which might predispose adolescents for systematic adverse health and behavioral alterations. These results extend the negative health risks associated with cigarette smoking to that of water-pipe tobacco smoking.
Authors: Karem H Alzoubi; Rahaf M Batran; Nour A Al-Sawalha; Omar F Khabour; Nareg Karaoghlanian; Alan Shihadeh; Thomas Eissenberg Journal: Inhal Toxicol Date: 2021-07-27 Impact factor: 3.011