| Literature DB >> 29555420 |
Eliot L Osher1, Francisco Castillo1, Nagarajan Elumalai1, Michael J Waring2, Garry Pairaudeau3, Ali Tavassoli4.
Abstract
We report an inhibitor of the homodimeric protein-protein interaction of the BCL6 oncoprotein, identified from a genetically encoded SICLOPPS library of 3.2 million cyclic hexapeptides in combination with a bacterial reverse two-hybrid system. This cyclic peptide is shown to bind the BTB domain of BCL6, disrupts its homodimerization, and subsequent binding of the SMRT2 corepressor peptide.Entities:
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Year: 2018 PMID： 29555420 DOI： 10.1016/j.bmc.2018.03.012
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641