Literature DB >> 29555060

Melanin nanoparticles: Antioxidant activities and effects on γ-ray-induced DNA damage in the mouse.

Monira M Rageh1, Reem H El-Gebaly2.   

Abstract

The radioprotective and antioxidant activities of melanin nanoparticles (MNP) were investigated in Chinese hamster ovary (CHO) cells in vitro and BALB/C mice in vivo. The endpoints measured were cell viability, superoxide dismutase (SOD) enzyme activity, malondialdehyde (MDA) levels, DNA damage (comet assay), and histopathological examination of tissues. Irradiated groups showed decreased SOD activity and increased MDA levels. Irradiation caused a 3-10-fold increase in comet parameters such as % tail DNA. Treatment with MNP protected cells from DNA damage and death, restored SOD activity, and decreased MDA production. Synthetic MNPs have both antioxidant and radioprotective activities.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  CHO cells; Comet assay; Histopathologiy; Malondialdehyde; Superoxide dismutase

Mesh：

Substances：

Year:  2018        PMID： 29555060     DOI： 10.1016/j.mrgentox.2018.01.009

Source DB:  PubMed          Journal:  Mutat Res Genet Toxicol Environ Mutagen        ISSN： 1383-5718            Impact factor:   2.873


  5 in total

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Authors:  Monira M Rageh; Reem H El-Gebaly; Marwa M Afifi
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  5 in total

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