Many runners as well as other athletes suffer from Achilles tendinopathy, considered to be induced predominantly by overuse.1, 2 There exist several treatment modalities compromising both conservative and surgical procedures, but therapy is not always successful and additional options would be desirable.1, 2Also fluoroquinolones like ciprofloxacin, frequently (probably too frequently) used for antibiotic therapy, can cause tendinopathy and at least in animals they induce also chondrotoxicity.3, 4 In animal experiments these adverse effects could significantly be diminished by dietary supplementation with magnesium and vitamin E.For more than 10 years I had suffered from Achilles tendinopathy and had experienced several injuries including partial rupture of one tendon. Eccentric training twice a day for six months (and continued thereafter at lower frequency) led to significant improvement, but some discomfort and moderate pain following longer workouts remained.So far I was not able to discover publications reporting treatment attempts with magnesium and/or vitamin E in humans. Encouraged by the remarkable results of the animal experiments cited above I decided to try this kind of treatment myself.I started to take 1 × 400 I.E. vitamin E and 2 × 150 mg magnesium citrate per day. After three months both discomfort and pain had completely disappeared.Based on this (admittedly anecdotal) observation and on the published animal experiments I propose that the effect of magnesium and vitamin E in patients experiencing Achilles tendinopathy should be investigated.I would appreciate if someone who is capable of doing this would perform a controlled clinical trial. If it turned out that I am not the only person responding to this simple treatment this could be a significant achievement for many athletes suffering from this widespread impairing condition.