Chang-Ching Wei1, Ji-Nan Sheu2, Jung-Tung Liu3, Sheng-Hui Yang4, I-Ching Chou5, Jeng-Dau Tsai6. 1. Children's Hospital, China Medical University Hospital, Taichung, Taiwan, ROC; School of Medicine, China Medical University, Taichung, Taiwan, ROC. 2. School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC; Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC. 3. School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC; Department of Neurosurgery, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC. 4. Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan, ROC. 5. Children's Hospital, China Medical University Hospital, Taichung, Taiwan, ROC; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC. 6. School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC; Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC. Electronic address: fernand.tsai@msa.hinet.net.
Abstract
BACKGROUND: Seizures in tuberous sclerosis complex (TSC) tend to be intractable over time and become a subsequent psychological burden for the patients. The purpose of the current study was to describe the onset, phenotype, and factors associated with seizure remission in patients with TSC. METHODS: Patients diagnosed with TSC between 2009 and 2015 completed a questionnaire interview and underwent a systematic evaluation, including a medical review of their epilepsy history and neurobehavioral disorder assessment. RESULTS: Of the 61 patients, 50 patients (82.0%) had a positive seizure history. The active (n = 34) and seizure remission (n = 16) groups showed significant differences in age, neurobehavioral disorder, history of refractory epilepsy, and onset age (p < 0.001, p < 0.05, p < 0.05, and p < 0.05, respectively). The remission rates were 33.3% and 38.5% for those aged 6-18 years and over 18 years, respectively (p for trend = 0.01). CONCLUSION: Seizure remission can occur in adulthood. It shows a high correlation with patient age, minor refractory epilepsy, and neurobehavioral disorders.
BACKGROUND:Seizures in tuberous sclerosis complex (TSC) tend to be intractable over time and become a subsequent psychological burden for the patients. The purpose of the current study was to describe the onset, phenotype, and factors associated with seizure remission in patients with TSC. METHODS:Patients diagnosed with TSC between 2009 and 2015 completed a questionnaire interview and underwent a systematic evaluation, including a medical review of their epilepsy history and neurobehavioral disorder assessment. RESULTS: Of the 61 patients, 50 patients (82.0%) had a positive seizure history. The active (n = 34) and seizure remission (n = 16) groups showed significant differences in age, neurobehavioral disorder, history of refractory epilepsy, and onset age (p < 0.001, p < 0.05, p < 0.05, and p < 0.05, respectively). The remission rates were 33.3% and 38.5% for those aged 6-18 years and over 18 years, respectively (p for trend = 0.01). CONCLUSION:Seizure remission can occur in adulthood. It shows a high correlation with patient age, minor refractory epilepsy, and neurobehavioral disorders.
Authors: Jean Christopher Chamcheu; Tithi Roy; Mohammad Burhan Uddin; Sergette Banang-Mbeumi; Roxane-Cherille N Chamcheu; Anthony L Walker; Yong-Yu Liu; Shile Huang Journal: Cells Date: 2019-07-31 Impact factor: 6.600