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Literature DB >> 29550614

Synthetic biology in probiotic lactic acid bacteria: At the frontier of living therapeutics.

Abstract

The trillions of microbes hosted by humans can dictate health or illness depending on a multitude of genetic, environmental, and lifestyle factors that help define the human ecosystem. As the human microbiota is characterized, so can the interconnectivity of microbe-host-disease be realized and manipulated. Designing microbes as therapeutic agents can not only enable targeted drug delivery but also restore homeostasis within a perturbed microbial community. Used for centuries in fermentation and preservation of food, lactic acid bacteria (LAB) have a long history of safe, and occasionally health promoting, interactions with the human gut, making them ideal candidates for engineered functionality. This review outlines available genetic tools, recent developments in biomedical applications, as well as potential future applications of synthetic biology to program LAB-based therapeutic systems.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2018 PMID： 29550614 PMCID： PMC6139064 DOI： 10.1016/j.copbio.2018.01.028

Source DB: PubMed Journal: Curr Opin Biotechnol ISSN： 0958-1669 Impact factor: 9.740

55 in total

1. AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis.

Authors: Silvia Caluwaerts; Klaas Vandenbroucke; Lothar Steidler; Sabine Neirynck; Peter Vanhoenacker; Sam Corveleyn; Brynmor Watkins; Stephen Sonis; Bernard Coulie; Pieter Rottiers
Journal: Oral Oncol Date: 2010-06-09 Impact factor: 5.337

2. Oral immunization of mice with engineered Lactobacillus gasseri NM713 strain expressing Streptococcus pyogenes M6 antigen.

Authors: Nahla M Mansour; Sahar A Abdelaziz
Journal: Microbiol Immunol Date: 2016-08 Impact factor: 1.955

3. Programmable probiotics for detection of cancer in urine.

Authors: Tal Danino; Arthur Prindle; Gabriel A Kwong; Matthew Skalak; Howard Li; Kaitlin Allen; Jeff Hasty; Sangeeta N Bhatia
Journal: Sci Transl Med Date: 2015-05-27 Impact factor: 17.956

4. Cloning, nucleotide sequence, and regulatory analysis of the Lactococcus lactis dnaJ gene.

Authors: M van Asseldonk; A Simons; H Visser; W M de Vos; G Simons
Journal: J Bacteriol Date: 1993-03 Impact factor: 3.490

5. A xylose-inducible expression system for Lactococcus lactis.

Authors: Anderson Miyoshi; Emmanuel Jamet; Jacqueline Commissaire; Pierre Renault; Philippe Langella; Vasco Azevedo
Journal: FEMS Microbiol Lett Date: 2004-10-15 Impact factor: 2.742

6. Improved stress tolerance of GroESL-overproducing Lactococcus lactis and probiotic Lactobacillus paracasei NFBC 338.

Authors: C Desmond; G F Fitzgerald; C Stanton; R P Ross
Journal: Appl Environ Microbiol Date: 2004-10 Impact factor: 4.792

7. Recombinant protein expression in Lactococcus lactis using the P170 expression system.

Authors: Casper M Jørgensen; Astrid Vrang; Søren M Madsen
Journal: FEMS Microbiol Lett Date: 2013-12-19 Impact factor: 2.742

Review 8. Use of probiotics in prevention and treatment of patients with Clostridium difficile infection.

Authors: Jacob E Ollech; Nicole T Shen; Carl V Crawford; Yehuda Ringel
Journal: Best Pract Res Clin Gastroenterol Date: 2016-01-14 Impact factor: 3.043

9. Engineering robust and tunable spatial structures with synthetic gene circuits.

Authors: Wentao Kong; Andrew E Blanchard; Chen Liao; Ting Lu
Journal: Nucleic Acids Res Date: 2016-11-28 Impact factor: 16.971

10. Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice.

Authors: Suguru Shigemori; Takafumi Watanabe; Kai Kudoh; Masaki Ihara; Shireen Nigar; Yoshinari Yamamoto; Yoshihito Suda; Takashi Sato; Haruki Kitazawa; Takeshi Shimosato
Journal: Microb Cell Fact Date: 2015-11-25 Impact factor: 5.328

17 in total

1. Angiotensin (1-7) delivered orally via probiotic, but not subcutaneously, benefits the gut-brain axis in older rats.

Authors: Thomas W Buford; Yi Sun; Lisa M Roberts; Anisha Banerjee; Sujitha Peramsetty; Anthony Knighton; Amrisha Verma; Drake Morgan; Gonzalo E Torres; Qiuhong Li; Christy S Carter
Journal: Geroscience Date: 2020-05-26 Impact factor: 7.713

2. Quantifying and Engineering Mucus Adhesion of Probiotics.

Authors: Zachary J S Mays; Todd C Chappell; Nikhil U Nair
Journal: ACS Synth Biol Date: 2020-01-13 Impact factor: 5.110

3. A quantitative model for metabolic intervention using gut microbes.

Authors: Zachary J S Mays; Nikhil U Nair
Journal: Biotechnol Prog Date: 2021-01-16

4. Delivery of IL-35 by Lactococcus lactis Ameliorates Collagen-Induced Arthritis in Mice.

Authors: Massimo Maddaloni; Irina Kochetkova; Carol Hoffman; David W Pascual
Journal: Front Immunol Date: 2018-11-20 Impact factor: 7.561

5. Galactose to tagatose isomerization at moderate temperatures with high conversion and productivity.

Authors: Josef R Bober; Nikhil U Nair
Journal: Nat Commun Date: 2019-10-07 Impact factor: 14.919

6. Application of A Novel Potential Probiotic Lactobacillus paracasei Strain Isolated from Kefir Grains in the Production of Feta-Type Cheese.

Authors: Ioanna Mantzourani; Antonia Terpou; Athanasios Alexopoulos; Pelagia Chondrou; Alex Galanis; Argyro Bekatorou; Eugenia Bezirtzoglou; Athanasios A Koutinas; Stavros Plessas
Journal: Microorganisms Date: 2018-11-29