Literature DB >> 295504

Does the duodenal cell ever return to normal? A comparison between treatment with cimetidine and denol.

M G Moshal, M A Gregory, C Pillay, J M Spitaels.   

Abstract

After six weeks therapy with the bismuth-containing substance Denol, the ultrastructure of the duodenal cell is normal in most cases. Following therapy with the histamine-2 receptor antagonist (cimetidine), for the same period and even after one year continuous therapy, the denodenal cell remains abnormal in most instances. This may explain the frequent relapse of duodenal ulcers after cimetidine treatment.

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Year:  1979        PMID: 295504

Source DB:  PubMed          Journal:  Scand J Gastroenterol Suppl        ISSN: 0085-5928


  12 in total

Review 1.  There is more to healing ulcers than suppressing acid.

Authors:  D G Colin-Jones
Journal:  Gut       Date:  1986-05       Impact factor: 23.059

2.  Relapse of duodenal ulcer: does it matter which drug is used in initial treatment?

Authors:  J P Miller; E B Faragher
Journal:  Br Med J (Clin Res Ed)       Date:  1986-11-01

3.  Acid, pepsin, and mucus secretion in patients with gastric and duodenal ulcer before and after colloidal bismuth subcitrate (De-Nol).

Authors:  J H Baron; J Barr; J Batten; R Sidebotham; J Spencer
Journal:  Gut       Date:  1986-05       Impact factor: 23.059

4.  Duodenal ulcers that will not heal.

Authors:  R E Pounder
Journal:  Gut       Date:  1984-07       Impact factor: 23.059

5.  Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate?

Authors: 
Journal:  Br Med J (Clin Res Ed)       Date:  1982-04-17

6.  Comparison of relapse rates and of mucosal abnormalities after healing of duodenal ulceration and after one year's maintenance with cimetidine or sucralfate: a light and electron microscopy study.

Authors:  F I Tovey; E M Husband; Y C Yiu; L Baker; G McPhail; M R Lewin; A P Jayaraj; C G Clark
Journal:  Gut       Date:  1989-05       Impact factor: 23.059

7.  Epidermal growth factor (EGF) in the gastroprotective and ulcer healing actions of colloidal bismuth subcitrate (De-Nol) in rats.

Authors:  S J Konturek; A Dembinski; Z Warzecha; W Bielanski; T Brzozowski; D Drozdowicz
Journal:  Gut       Date:  1988-07       Impact factor: 23.059

8.  Relative contribution of mucosal injury and Helicobacter pylori in the development of gastroduodenal lesions in patients taking non-steroidal anti-inflammatory drugs.

Authors:  C J Hawkey; J Naesdal; I Wilson; G Långström; A J Swannell; R A Peacock; N D Yeomans
Journal:  Gut       Date:  2002-09       Impact factor: 23.059

9.  Uptake and subcellular localisation of bismuth in the gastrointestinal mucosa of rats after short term administration of colloidal bismuth subcitrate.

Authors:  D Stiel; D J Murray; T J Peters
Journal:  Gut       Date:  1985-04       Impact factor: 23.059

10.  Healing and recurrence of duodenal ulcer after treatment with tripotassium dicitrato bismuthate (TDB) tablets or cimetidine.

Authors:  I Hamilton; H J O'Connor; N C Wood; I Bradbury; A T Axon
Journal:  Gut       Date:  1986-01       Impact factor: 23.059

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