| Literature DB >> 29550258 |
Chengchao Ding1, Junfei Ma1, Qingli Dong1, Qing Liu2.
Abstract
Live bacteria, including attenuated bacteria and probiotics, can be engineered to deliver target antigen to excite the host immune system. The preponderance of these live bacterial vaccine vectors is that they can stimulate durable humoral and cellular immunity. Moreover, delivery strategies of heterologous antigen in live bacterial promote the applications of new vaccine development. Genetic technologies are evolving, which potentiate the developing of heterologous antigen delivery systems, including bacterial surface display system, bacterial secretion system and balanced lethal vector system. Although the live bacterial vaccine vector is a powerful adjuvant, certain disadvantages, such as safety risk, must also be taken into account. In this review, we compare the development of representative live bacterial vectors, and summarize the main characterizations of the various delivery strategies of heterologous antigen in live vector vaccines. Published by Elsevier B.V.Keywords: Attenuated bacteria; Bacterial secretion system; Bacterial surface display system; Balanced lethal vector system; Live bacterial vaccine vector; Probiotic
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Year: 2018 PMID： 29550258 DOI： 10.1016/j.imlet.2018.03.006
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685