Benedetta Vanini1, Valentina Grazioli2, Antonio Sciortino2, Maurizio Pin2, Vera N Merli2, Anna Celentano2, Ilaria Parisi2, Catherine Klersy3, Lucia Petrucci4, Maurizio Salati2, Pierluigi Politi5, Andrea M D'Armini2. 1. Unit of Cardiac Surgery, Intrathoracic Transplantation and Pulmonary Hypertension, University of Pavia School of Medicine, Foundation IRCCS Policlinico San Matteo, Pavia, Italy; Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy. Electronic address: benedetta.vanini@virgilio.it. 2. Unit of Cardiac Surgery, Intrathoracic Transplantation and Pulmonary Hypertension, University of Pavia School of Medicine, Foundation IRCCS Policlinico San Matteo, Pavia, Italy. 3. Service of Biometrics and Statistics, Foundation IRCCS Policlinico San Matteo, Pavia, Italy. 4. Rehabilitation Unit, Foundation IRCCS Policlinico San Matteo, Pavia, Italy. 5. Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy.
Abstract
BACKGROUND: In this prospective, single-center, observational study, we investigated the association between repeated short periods of circulatory arrest with moderate hypothermia during pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and different neuropsychological dimensions. METHODS: We examined 70 patients with CTEPH, >18 to 80 years of age, who had been treated with PEA. Neuropsychological testing was performed. RESULTS: Learning ability and delayed memory remained well within the normal range for patients' age. We found a statistically significant post-surgical improvement in motor speed, which was accompanied by a better quality of life and reduced symptoms of depression and anxiety. CONCLUSION: PEA with repeated short periods of circulatory arrest in CTEPH did not result in any neuropsychological complications and may even lead to post-surgical psychological improvements.
BACKGROUND: In this prospective, single-center, observational study, we investigated the association between repeated short periods of circulatory arrest with moderate hypothermia during pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and different neuropsychological dimensions. METHODS: We examined 70 patients with CTEPH, >18 to 80 years of age, who had been treated with PEA. Neuropsychological testing was performed. RESULTS:Learning ability and delayed memory remained well within the normal range for patients' age. We found a statistically significant post-surgical improvement in motor speed, which was accompanied by a better quality of life and reduced symptoms of depression and anxiety. CONCLUSION:PEA with repeated short periods of circulatory arrest in CTEPH did not result in any neuropsychological complications and may even lead to post-surgical psychological improvements.
Authors: Andrea M D'Armini; Anna Celentano; Alessia Alloni; Giuseppe Silvaggio; Cristian Monterosso; Carlo Pellegrini; Stefano Ghio Journal: Ann Cardiothorac Surg Date: 2022-03
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