Gary Tse1, Mengqi Gong2, Lei Meng2, Cheuk Wai Wong3, Stamatis Georgopoulos4, George Bazoukis4, Martin C S Wong5, Konstantinos P Letsas4, Vassilios S Vassiliou6, Yunlong Xia7, Adrian M Baranchuk8, Gan-Xin Yan9, Tong Liu10. 1. Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China. Electronic address: tseg@cuhk.edu.hk. 2. Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China. 3. Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. 4. Second Department of Cardiology, Laboratory of Cardiac Electrophysiology, "Evangelismos" General Hospital of Athens, Athens, Greece. 5. JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China. 6. Norwich Medical School, University of East Anglia, Bob Champion Research & Education Building, James Watson Road, Norwich, UK; Royal Brompton Hospital and Imperial College London, UK. 7. Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, China. 8. Division of Cardiology, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada. 9. Lankenau Institute for Medical Research and Lankenau Medical Center, Wynnewood, PA, USA; Beijing Anzhen Hospital, Capital Medical University, Beijing, China. 10. Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China. Electronic address: liutongdoc@126.com.
Abstract
BACKGROUND AND OBJECTIVES: Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death. The Tpeak-Tend interval and the Tpeak-Tend/QT ratio, electrocardiographic markers of dispersion of ventricular repolarization, were proposed for risk stratification but their predictive values in LQTS have been controversial. A systematic review and meta-analysis was conducted to examine the value of Tpeak-Tend intervals and Tpeak-Tend/QT ratios in predicting arrhythmic and mortality outcomes in congenital LQTS. METHOD: PubMed and Embase databases were searched until 9th May 2017, identifying 199 studies. RESULTS: Five studies on long QT syndrome were included in the final meta-analysis. Tpeak-Tend intervals were longer (mean difference [MD]: 13ms, standard error [SE]: 4ms, P=0.002; I2=34%) in congenital LQTS patients with adverse events [syncope, ventricular arrhythmias or sudden cardiac death] compared to LQTS patients without such events. By contrast, Tpeak-Tend/QT ratios were not significantly different between the two groups (MD: 0.02, SE: 0.02, P=0.26; I2=0%). CONCLUSION: This meta-analysis showed that Tpeak-Tend interval is significant higher in individuals who are at elevated risk of adverse events in congenital LQTS, offering incremental value for risk stratification.
BACKGROUND AND OBJECTIVES:Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death. The Tpeak-Tend interval and the Tpeak-Tend/QT ratio, electrocardiographic markers of dispersion of ventricular repolarization, were proposed for risk stratification but their predictive values in LQTS have been controversial. A systematic review and meta-analysis was conducted to examine the value of Tpeak-Tend intervals and Tpeak-Tend/QT ratios in predicting arrhythmic and mortality outcomes in congenital LQTS. METHOD: PubMed and Embase databases were searched until 9th May 2017, identifying 199 studies. RESULTS: Five studies on long QT syndrome were included in the final meta-analysis. Tpeak-Tend intervals were longer (mean difference [MD]: 13ms, standard error [SE]: 4ms, P=0.002; I2=34%) in congenital LQTS patients with adverse events [syncope, ventricular arrhythmias or sudden cardiac death] compared to LQTS patients without such events. By contrast, Tpeak-Tend/QT ratios were not significantly different between the two groups (MD: 0.02, SE: 0.02, P=0.26; I2=0%). CONCLUSION: This meta-analysis showed that Tpeak-Tend interval is significant higher in individuals who are at elevated risk of adverse events in congenital LQTS, offering incremental value for risk stratification.
Authors: Gary Tse; George Bazoukis; Leonardo Roever; Tong Liu; William K K Wu; Martin C S Wong; Adrian Baranchuk; Panagiotis Korantzopoulos; Dimitrios Asvestas; Konstantinos P Letsas Journal: Curr Atheroscler Rep Date: 2018-09-17 Impact factor: 5.113
Authors: Weiding Wang; Xu Zhang; Kangyin Chen; Li Yin; Mengqi Gong; Yang Liu; Gary Tse; Lin Wu; Guangping Li; Tong Liu Journal: Ann Noninvasive Electrocardiol Date: 2019-12-17 Impact factor: 1.468
Authors: Gary Tse; Mengqi Gong; Lei Meng; Cheuk W Wong; George Bazoukis; Matthew T V Chan; Martin C S Wong; Konstantinos P Letsas; Adrian Baranchuk; Gan-Xin Yan; Tong Liu; William K K Wu Journal: Front Physiol Date: 2018-09-03 Impact factor: 4.566