Literature DB >> 29548878

Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR.

Verena Hiebl1, Angela Ladurner2, Simone Latkolik1, Verena M Dirsch1.   

Abstract

Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-related diseases. In addition, natural products are an interesting pool of potential ligands since they have been refined under evolutionary pressure to interact with proteins or other biological targets. This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid X receptors (FXR) that form permissive heterodimers with retinoid X receptors (RXR). Natural product-based ligands for these receptors are summarized and the potential of LXR, FXR and RXR as targets in precision medicine is discussed.
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Farnesoid X receptor; Liver X receptor; Metabolic syndrome; Natural products; Nuclear receptors; Precision medicine; Retinoid X receptor

Mesh：

Substances：

Year:  2018        PMID： 29548878     DOI： 10.1016/j.biotechadv.2018.03.003

Source DB:  PubMed          Journal:  Biotechnol Adv        ISSN： 0734-9750            Impact factor:   14.227


  25 in total

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