Daniëlle Bp Eekers1, Lieke In 't Ven2, Erik Roelofs3, Alida Postma4, Claire Alapetite5, Neil G Burnet6, Valentin Calugaru7, Inge Compter2, Ida E M Coremans8, Morton Høyer9, Maarten Lambrecht10, Petra Witt Nyström11, Alejandra Méndez Romero12, Frank Paulsen13, Ana Perpar14, Dirk de Ruysscher15, Laurette Renard16, Beate Timmermann17, Pavel Vitek18, Damien C Weber19, Hiske L van der Weide20, Gillian A Whitfield21, Ruud Wiggenraad22, Esther G C Troost23. 1. Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands; Proton Therapy Department South-East Netherlands (ZON-PTC), Maastricht, The Netherlands. Electronic address: danielle.eekers@maastro.nl. 2. Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands. 3. Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands; The-D Lab: Decision Support for Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre+, The Netherlands. 4. Department of Radiology and Nuclear Medicine MUMC+, Maastricht, The Netherlands. 5. Institut Curie, Radiation Oncology Department, Paris & Proton Center, Orsay, France. 6. University of Cambridge Department of Oncology, Addenbrooke's Hospital, United Kingdom. 7. Institute Curie, Paris, France; Institute Curie, Centre de Protonthérapie d'Orsay, Orsay, France. 8. Leiden University Medical Centre, Department of Radiotherapy, The Netherlands; Holland Proton Therapy Centre, Delft, The Netherlands. 9. Danish Center for Particle Therapy, Aarhus, Denmark. 10. Department of Radiotherapy-Oncology, Leuven Kanker Instituut, UZ Gasthuisberg, Belgium. 11. The Skandion Clinic, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Sweden. 12. Holland Proton Therapy Centre, Delft, The Netherlands; Erasmus Medical Centre, Rotterdam, The Netherlands. 13. Department of Radiation Oncology, Eberhard-Carls-Universität Tübingen, Germany. 14. EBG MedAustron GmbH, Wiener Neustadt, Austria. 15. Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands; Department of Radiotherapy-Oncology, Leuven Kanker Instituut, UZ Gasthuisberg, Belgium. 16. Service de Radiothérapie Oncologique Cliniques universitaires St Luc, Brussels, Belgium. 17. Clinic for Particle Therapy, University Hospital Essen, West German Cancer Center (WTZ), Germany; West German Proton Therapy Center Essen (WPE), Germany; German Cancer Consortium (DKTK), partnersite Essen, Essen, Germany. 18. Proton Therapy Center Czech, Prague, Czech Republic. 19. Paul Scherrer Institut med. Center for Proton Therapy, Switzerland. 20. Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands. 21. The University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, United Kingdom; The Children's Brain Tumour Research Network, University of Manchester, Royal Manchester Children's Hospital, United Kingdom. 22. Holland Proton Therapy Centre, Delft, The Netherlands; Haaglanden Medisch Centrum, Department of Radiotherapy, Leidschendam, The Netherlands. 23. Department of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; OncoRay - National Center for Radiation Research in Oncology, Dresden, Germany; German Cancer Consortium (DKTK), partnersite Dresden, Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), partnersite Dresden, Dresden, Germany.
Abstract
PURPOSE: To create a digital, online atlas for organs at risk (OAR) delineation in neuro-oncology based on high-quality computed tomography (CT) and magnetic resonance (MR) imaging. METHODS: CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent) were obtained from the same patient and subsequently fused. In addition, a 7T MR without intravenous contrast agent was obtained from a healthy volunteer. Based on discussion between experienced radiation oncologists, the clinically relevant organs at risk (OARs) to be included in the atlas for neuro-oncology were determined, excluding typical head and neck OARs previously published. The draft atlas was delineated by a senior radiation oncologist, 2 residents in radiation oncology, and a senior neuro-radiologist incorporating relevant available literature. The proposed atlas was then critically reviewed and discussed by European radiation oncologists until consensus was reached. RESULTS: The online atlas includes one CT-scan at two different window settings and one MR scan (3T) showing the OARs in axial, coronal and sagittal view. This manuscript presents the three-dimensional descriptions of the fifteen consensus OARs for neuro-oncology. Among these is a new OAR relevant for neuro-cognition, the posterior cerebellum (illustrated on 7T MR images). CONCLUSION: In order to decrease inter- and intra-observer variability in delineating OARs relevant for neuro-oncology and thus derive consistent dosimetric data, we propose this atlas to be used in photon and particle therapy. The atlas is available online at www.cancerdata.org and will be updated whenever required.
PURPOSE: To create a digital, online atlas for organs at risk (OAR) delineation in neuro-oncology based on high-quality computed tomography (CT) and magnetic resonance (MR) imaging. METHODS: CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent) were obtained from the same patient and subsequently fused. In addition, a 7T MR without intravenous contrast agent was obtained from a healthy volunteer. Based on discussion between experienced radiation oncologists, the clinically relevant organs at risk (OARs) to be included in the atlas for neuro-oncology were determined, excluding typical head and neck OARs previously published. The draft atlas was delineated by a senior radiation oncologist, 2 residents in radiation oncology, and a senior neuro-radiologist incorporating relevant available literature. The proposed atlas was then critically reviewed and discussed by European radiation oncologists until consensus was reached. RESULTS: The online atlas includes one CT-scan at two different window settings and one MR scan (3T) showing the OARs in axial, coronal and sagittal view. This manuscript presents the three-dimensional descriptions of the fifteen consensus OARs for neuro-oncology. Among these is a new OAR relevant for neuro-cognition, the posterior cerebellum (illustrated on 7T MR images). CONCLUSION: In order to decrease inter- and intra-observer variability in delineating OARs relevant for neuro-oncology and thus derive consistent dosimetric data, we propose this atlas to be used in photon and particle therapy. The atlas is available online at www.cancerdata.org and will be updated whenever required.
Authors: Angela Sekely; Derek S Tsang; Donald Mabbott; Paul Kongkham; Gelareh Zadeh; Konstantine K Zakzanis; Kim Edelstein Journal: Neurooncol Pract Date: 2022-02-19
Authors: Daniëlle B P Eekers; Lieke In 't Ven; Sabine Deprez; Linda Jacobi; Erik Roelofs; Ann Hoeben; Philippe Lambin; Dirk de Ruysscher; Esther G C Troost Journal: Clin Transl Radiat Oncol Date: 2017-11-23
Authors: Annika Hänsch; Jan Hendrik Moltz; Benjamin Geisler; Christiane Engel; Jan Klein; Angelo Genghi; Jan Schreier; Tomasz Morgas; Benjamin Haas Journal: J Med Imaging (Bellingham) Date: 2020-11-11
Authors: Yvonne Dzierma; Michaela Schuermann; Patrick Melchior; Frank Nuesken; Joachim Oertel; Christian Rübe; Philipp Hendrix Journal: Front Oncol Date: 2021-02-26 Impact factor: 6.244
Authors: Lieke In 't Ven; Erik Roelofs; Macarena Cubillos Mesías; Inge Compter; Yvonne L B Klaver; Robert Jan Smeenk; Geert O Janssens; Johannes H A M Kaanders; Raquel Davila Fajardo; Foppe Oldenburger; Dirk de Ruysscher; Esther G C Troost; Daniëlle B P Eekers Journal: Clin Transl Radiat Oncol Date: 2021-02-22