Literature DB >> 2954856

Lipocortin inhibition of extracellular and intracellular phospholipases A2 is substrate concentration dependent.

A J Aarsman, G Mynbeek, H van den Bosch, B Rothhut, B Prieur, C Comera, L Jordan, F Russo-Marie.   

Abstract

Hydrolysis of Escherichia coli membrane phospholipids by pancreatic phospholipase A2 was inhibited by lipocortin from human monocytes in a substrate dependent manner. Inhibition was completely overcome at substrate concentrations above 250 microM. Lipocortin also inhibited partially purified preparations of two intracellular phospholipases A2 isolated from rat liver mitochondria and rat platelets when these enzymes were assayed at low micromolar concentrations of phosphatidylethanolamine. Inhibition gradually decreased with increasing substrate concentrations both for pancreatic and platelet phospholipase A2 and became completely abolished above 15 and 50 microM phosphatidylethanolamine, respectively.

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Year:  1987        PMID： 2954856     DOI： 10.1016/0014-5793(87)81212-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

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Authors:  L Hasselmark; R Malmgren; A Dumitrescu
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Review 2.  Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids.

Authors:  R J Flower
Journal:  Br J Pharmacol       Date:  1988-08       Impact factor: 8.739

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4.  Immunohistochemical localization of lipocortins in normal and psoriatic human skin.

Authors:  K Ikai; K Shimizu; Y Ando; F Furukawa; S Imamura; R Kannagi
Journal:  Arch Dermatol Res       Date:  1993       Impact factor: 3.017

5.  A 32 kDa lipocortin from human mononuclear cells appears to be identical with the placental inhibitor of blood coagulation.

Authors:  B Rothhut; C Coméra; S Cortial; P Y Haumont; K H Diep Le; J C Cavadore; J Conard; F Russo-Marie; F Lederer
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

6.  Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

Authors:  J L Masferrer; B S Zweifel; K Seibert; P Needleman
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7.  Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo-oxygenase/PGE isomerase.

Authors:  M Goppelt-Struebe; D Wolter; K Resch
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

8.  Annexin 5 as a potential regulator of annexin 1 phosphorylation by protein kinase C. In vitro inhibition compared with quantitative data on annexin distribution in human endothelial cells.

Authors:  P Raynal; F Hullin; J M Ragab-Thomas; J Fauvel; H Chap
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

9.  Phospholipase A2--regulation and inhibition.

Authors:  W Scheuer
Journal:  Klin Wochenschr       Date:  1989-02-01

10.  Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases.

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Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205
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