Literature DB >> 29547801

Antifungal drug resistance: evolution, mechanisms and impact.

Nicole M Revie1, Kali R Iyer1, Nicole Robbins1, Leah E Cowen2.   

Abstract

Microorganisms have a remarkable capacity to evolve resistance to antimicrobial agents, threatening the efficacy of the limited arsenal of antimicrobials and becoming a dire public health crisis. This is of particular concern for fungal pathogens, which cause devastating invasive infections with treatment options limited to only three major classes of antifungal drugs. The paucity of antifungals with clinical utility is in part due to close evolutionary relationships between these eukaryotic pathogens and their human hosts, which limits the unique targets to be exploited therapeutically. This review highlights the mechanisms by which fungal pathogens of humans evolve resistance to antifungal drugs, which provide crucial insights to enable development of novel therapeutic strategies to thwart drug resistance and combat fungal infectious disease.
Copyright © 2018 Elsevier Ltd. All rights reserved.

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Year:  2018        PMID： 29547801      PMCID： PMC6135714          DOI： 10.1016/j.mib.2018.02.005

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  53 in total

1.  Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

Authors:  Dominique Sanglard; Françoise Ischer; Michel Monod; Jacques Bille
Journal:  Microbiology (Reading)       Date:  1997-02       Impact factor: 2.777

2.  An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1.

Authors:  Anna Selmecki; Maryam Gerami-Nejad; Carsten Paulson; Anja Forche; Judith Berman
Journal:  Mol Microbiol       Date:  2008-03-20       Impact factor: 3.501

3.  Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses.

Authors:  Shawn R Lockhart; Kizee A Etienne; Snigdha Vallabhaneni; Joveria Farooqi; Anuradha Chowdhary; Nelesh P Govender; Arnaldo Lopes Colombo; Belinda Calvo; Christina A Cuomo; Christopher A Desjardins; Elizabeth L Berkow; Mariana Castanheira; Rindidzani E Magobo; Kauser Jabeen; Rana J Asghar; Jacques F Meis; Brendan Jackson; Tom Chiller; Anastasia P Litvintseva
Journal:  Clin Infect Dis       Date:  2016-10-20       Impact factor: 9.079

Review 4.  Regulatory circuitry governing fungal development, drug resistance, and disease.

Authors:  Rebecca S Shapiro; Nicole Robbins; Leah E Cowen
Journal:  Microbiol Mol Biol Rev       Date:  2011-06       Impact factor: 11.056

5.  Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.

Authors:  Leah E Cowen; Sheena D Singh; Julia R Köhler; Cathy Collins; Aimee K Zaas; Wiley A Schell; Hamza Aziz; Eleftherios Mylonakis; John R Perfect; Luke Whitesell; Susan Lindquist
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-05       Impact factor: 11.205

6.  Chemogenomic Profiling of the Fungal Pathogen Candida albicans.

Authors:  Yaolin Chen; Jaideep Mallick; Alaa Maqnas; Yuan Sun; Baharul I Choudhury; Pierre Côte; Lan Yan; Ting-Jun-Hong Ni; Yan Li; Dazhi Zhang; Roberto Rodríguez-Ortiz; Quan-Zhen Lv; Yuan-Ying Jiang; Malcolm Whiteway
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

7.  Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.

Authors:  Sheena D Singh; Nicole Robbins; Aimee K Zaas; Wiley A Schell; John R Perfect; Leah E Cowen
Journal:  PLoS Pathog       Date:  2009-07-31       Impact factor: 6.823

8.  A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.

Authors:  Sven D Willger; Srisombat Puttikamonkul; Kwang-Hyung Kim; James B Burritt; Nora Grahl; Laurel J Metzler; Robert Barbuch; Martin Bard; Christopher B Lawrence; Robert A Cramer
Journal:  PLoS Pathog       Date:  2008-11-07       Impact factor: 6.823

9.  The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans.

Authors:  Joachim Morschhäuser; Katherine S Barker; Teresa T Liu; Julia BlaB-Warmuth; Ramin Homayouni; P David Rogers
Journal:  PLoS Pathog       Date:  2007-11       Impact factor: 6.823

10.  The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.

Authors:  Jinglin L Xie; Longguang Qin; Zhengqiang Miao; Ben T Grys; Jacinto De La Cruz Diaz; Kenneth Ting; Jonathan R Krieger; Jiefei Tong; Kaeling Tan; Michelle D Leach; Troy Ketela; Michael F Moran; Damian J Krysan; Charles Boone; Brenda J Andrews; Anna Selmecki; Koon Ho Wong; Nicole Robbins; Leah E Cowen
Journal:  Nat Commun       Date:  2017-09-11       Impact factor: 14.919
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  75 in total

Review 1.  Antimicrobial host defence peptides: functions and clinical potential.

Authors:  Neeloffer Mookherjee; Marilyn A Anderson; Henk P Haagsman; Donald J Davidson
Journal:  Nat Rev Drug Discov       Date:  2020-02-27       Impact factor: 84.694

2.  Transcriptomics analysis of propiconazole-treated Cochliobolus sativus reveals new putative azole targets in the plant pathogen.

Authors:  Deepika Somani; Ragini Adhav; Ramya Prashant; Narendra Y Kadoo
Journal:  Funct Integr Genomics       Date:  2019-03-06       Impact factor: 3.410

3.  Pathogenic budding yeasts isolated outside of clinical settings.

Authors:  Dana A Opulente; Quinn K Langdon; Kelly V Buh; Max A B Haase; Kayla Sylvester; Ryan V Moriarty; Martin Jarzyna; Samantha L Considine; Rachel M Schneider; Chris Todd Hittinger
Journal:  FEMS Yeast Res       Date:  2019-05-01       Impact factor: 2.796

Review 4.  Antifungal Resistance: a Concerning Trend for the Present and Future.

Authors:  Joshua A Hendrickson; Chenlin Hu; Samuel L Aitken; Nicholas Beyda
Journal:  Curr Infect Dis Rep       Date:  2019-11-16       Impact factor: 3.725

5.  Prospective CYP2C19-Guided Voriconazole Prophylaxis in Patients With Neutropenic Acute Myeloid Leukemia Reduces the Incidence of Subtherapeutic Antifungal Plasma Concentrations.

Authors:  J Kevin Hicks; Rod E Quilitz; Rami S Komrokji; Timothy E Kubal; Jeffrey E Lancet; Yanina Pasikhova; Dahui Qin; Wonhee So; Gisela Caceres; Kerry Kelly; Yasmina S Salchert; Kevin Shahbazian; Farnoosh Abbas-Aghababazadeh; Brooke L Fridley; Ana P Velez; Howard L McLeod; John N Greene
Journal:  Clin Pharmacol Ther       Date:  2019-11-01       Impact factor: 6.875

Review 6.  Structure-guided approaches to targeting stress responses in human fungal pathogens.

Authors:  Emmanuelle V LeBlanc; Elizabeth J Polvi; Amanda O Veri; Gilbert G Privé; Leah E Cowen
Journal:  J Biol Chem       Date:  2020-08-12       Impact factor: 5.157

7.  Dysfunction of Prohibitin 2 Results in Reduced Susceptibility to Multiple Antifungal Drugs via Activation of the Oxidative Stress-Responsive Transcription Factor Pap1 in Fission Yeast.

Authors:  Qiannan Liu; Fan Yao; Guanglie Jiang; Min Xu; Si Chen; Lina Zhou; Norihiro Sakamoto; Takayoshi Kuno; Yue Fang
Journal:  Antimicrob Agents Chemother       Date:  2018-10-24       Impact factor: 5.191

8.  Fluconazole analogues with metal-binding motifs impact metal-dependent processes and demonstrate antifungal activity in Candida albicans.

Authors:  Elizabeth W Hunsaker; Katherine J McAuliffe; Katherine J Franz
Journal:  J Biol Inorg Chem       Date:  2020-06-15       Impact factor: 3.358

9.  Cathelicidin-inspired antimicrobial peptides as novel antifungal compounds.

Authors:  Martin van Eijk; Stephanie Boerefijn; Lida Cen; Marisela Rosa; Marnix J H Morren; Cornelis K van der Ent; Bart Kraak; Jan Dijksterhuis; Ivan D Valdes; Henk P Haagsman; Hans de Cock
Journal:  Med Mycol       Date:  2020-11-10       Impact factor: 4.076

10.  NADPH-Cytochrome P450 Reductase Ccr1 Is a Target of Tamoxifen and Participates in Its Antifungal Activity via Regulating Cell Wall Integrity in Fission Yeast.

Authors:  Qiannan Liu; Xiaoxu Guo; Guanglie Jiang; Guoxiang Wu; Hao Miao; Kun Liu; Si Chen; Norihiro Sakamoto; Takayoshi Kuno; Fan Yao; Yue Fang
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191
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