Literature DB >> 29547719

Ubiquilin 2: Shuttling Clients Out of Phase?

Ipsita Subudhi1, James Shorter2.   

Abstract

Ubiquilin 2 (UBQLN2) is an amyotrophic lateral sclerosis-linked molecular chaperone with a prion-like domain that directly engages ubiquitin to triage clients for proteasomal degradation. Dao et al. (2018) now establish that UBQLN2 forms ubiquitin-labile liquids, which may enable UBQLN2 to specifically extract ubiquitylated clients from stress granules for degradation.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29547719      PMCID： PMC5966015          DOI： 10.1016/j.molcel.2018.02.030

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  10 in total

1.  Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.

Authors:  Cara Rothenberg; Deepa Srinivasan; Leann Mah; Susmita Kaushik; Corrine M Peterhoff; Janet Ugolino; Shengyun Fang; Ana Maria Cuervo; Ralph A Nixon; Mervyn J Monteiro
Journal:  Hum Mol Genet       Date:  2010-06-07       Impact factor: 6.150

Review 2.  Designer protein disaggregases to counter neurodegenerative disease.

Authors:  James Shorter
Journal:  Curr Opin Genet Dev       Date:  2017-02-14       Impact factor: 5.578

3.  Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains.

Authors:  Han Seok Ko; Takashi Uehara; Kazuhiro Tsuruma; Yasuyuki Nomura
Journal:  FEBS Lett       Date:  2004-05-21       Impact factor: 4.124

4.  Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions.

Authors:  Thuy P Dao; Regina-Maria Kolaitis; Hong Joo Kim; Kevin O'Donovan; Brian Martyniak; Erica Colicino; Heidi Hehnly; J Paul Taylor; Carlos A Castañeda
Journal:  Mol Cell       Date:  2018-03-08       Impact factor: 17.970

5.  Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.

Authors:  Han-Xiang Deng; Wenjie Chen; Seong-Tshool Hong; Kym M Boycott; George H Gorrie; Nailah Siddique; Yi Yang; Faisal Fecto; Yong Shi; Hong Zhai; Hujun Jiang; Makito Hirano; Evadnie Rampersaud; Gerard H Jansen; Sandra Donkervoort; Eileen H Bigio; Benjamin R Brooks; Kaouther Ajroud; Robert L Sufit; Jonathan L Haines; Enrico Mugnaini; Margaret A Pericak-Vance; Teepu Siddique
Journal:  Nature       Date:  2011-08-21       Impact factor: 49.962

6.  UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.

Authors:  Roland Hjerpe; John S Bett; Matthew J Keuss; Alexandra Solovyova; Thomas G McWilliams; Clare Johnson; Indrajit Sahu; Joby Varghese; Nicola Wood; Melanie Wightman; Georgina Osborne; Gillian P Bates; Michael H Glickman; Matthias Trost; Axel Knebel; Francesco Marchesi; Thimo Kurz
Journal:  Cell       Date:  2016-07-28       Impact factor: 41.582

7.  A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis.

Authors:  Brittany M Edens; Jianhua Yan; Nimrod Miller; Han-Xiang Deng; Teepu Siddique; Yongchao C Ma
Journal:  Elife       Date:  2017-05-02       Impact factor: 8.140

Review 8.  Principles and Properties of Stress Granules.

Authors:  David S W Protter; Roy Parker
Journal:  Trends Cell Biol       Date:  2016-06-09       Impact factor: 20.808

9.  Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.

Authors:  Eisuke Itakura; Eszter Zavodszky; Sichen Shao; Matthew L Wohlever; Robert J Keenan; Ramanujan S Hegde
Journal:  Mol Cell       Date:  2016-06-23       Impact factor: 17.970

Review 10.  Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease.

Authors:  Zachary M March; Oliver D King; James Shorter
Journal:  Brain Res       Date:  2016-03-18       Impact factor: 3.252
  10 in total
  3 in total

1.  Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.

Authors:  Xiang Chen; Danielle L Ebelle; Brandon J Wright; Vinidhra Sridharan; Evan Hooper; Kylie J Walters
Journal:  J Mol Biol       Date:  2019-01-18       Impact factor: 5.469

2.  The STI1-domain is a flexible alpha-helical fold with a hydrophobic groove.

Authors:  Michelle Y Fry; Shyam M Saladi; William M Clemons
Journal:  Protein Sci       Date:  2021-03-04       Impact factor: 6.725

Review 3.  Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?

Authors:  Anna Ainslie; Wouter Huiting; Lara Barazzuol; Steven Bergink
Journal:  Open Biol       Date:  2021-04-21       Impact factor: 6.411
  3 in total

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