Literature DB >> 29546669

Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility.

Lijun Ding1,2, Guijun Yan1, Bin Wang2, Lu Xu1, Yan Gu3, Tong Ru3, Xiaoying Cui1, Lei Lei1, Jingyu Liu1, Xiaoqiang Sheng1, Bin Wang2, Chunxue Zhang1, Yanjun Yang1, Ruiwei Jiang1, Jianjun Zhou1, Na Kong1, Feifei Lu1, Huaijun Zhou3, Yannan Zhao4, Bing Chen4, Yali Hu5, Jianwu Dai6, Haixiang Sun7.   

Abstract

Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF.

Entities:  

Keywords:  FOXO1; FOXO3a; UC-MSCs; collagen scaffold; granulosa cells; premature ovarian failure; primordial follicle activation

Mesh：

Substances：

Year:  2018        PMID： 29546669     DOI： 10.1007/s11427-017-9272-2

Source DB:  PubMed          Journal:  Sci China Life Sci        ISSN： 1674-7305            Impact factor:   6.038


  43 in total

1.  HucMSC-Derived Exosomes Mitigate the Age-Related Retardation of Fertility in Female Mice.

Authors:  Weijie Yang; Jing Zhang; Boqun Xu; Yuanlin He; Wei Liu; Jiazhao Li; Songying Zhang; Xiaona Lin; Dongming Su; Tinghe Wu; Jing Li
Journal:  Mol Ther       Date:  2020-02-07       Impact factor: 11.454

2.  Human Umbilical Cord Mesenchymal Stem Cells Improve Ovarian Function in Chemotherapy-Induced Premature Ovarian Failure Mice Through Inhibiting Apoptosis and Inflammation via a Paracrine Mechanism.

Authors:  Taoran Deng; Jing He; Qingyun Yao; Linjing Wu; Liru Xue; Mingfu Wu; Dongcheng Wu; Changyong Li; Yufeng Li
Journal:  Reprod Sci       Date:  2021-03-09       Impact factor: 3.060

Review 3.  Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell.

Authors:  Akimasa Takahashi; Abdelrahman Yousif; Linda Hong; IIana Chefetz
Journal:  J Mol Med (Berl)       Date:  2021-02-27       Impact factor: 4.599

Review 4.  Human Mesenchymal Stem Cell Therapy and Other Novel Treatment Approaches for Premature Ovarian Insufficiency.

Authors:  Mara Ulin; Esra Cetin; Elie Hobeika; Rishi Man Chugh; Hang-Soo Park; Sahar Esfandyari; Ayman Al-Hendy
Journal:  Reprod Sci       Date:  2021-05-06       Impact factor: 3.060

5.  Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway.

Authors:  Hanwen Liu; Chunyan Jiang; Boya La; Meng Cao; Song Ning; Jing Zhou; Zhengjie Yan; Chuyu Li; Yugui Cui; Xiang Ma; Meilian Wang; Li Chen; Youjia Yu; Feng Chen; Yuexin Zhang; Huimin Wu; Jiayin Liu; Lianju Qin
Journal:  Stem Cell Res Ther       Date:  2021-06-02       Impact factor: 6.832

Review 6.  Therapeutic Potential of HUMSCs in Female Reproductive Aging.

Authors:  Qiaojuan Mei; Hongbei Mou; Xuemei Liu; Wenpei Xiang
Journal:  Front Cell Dev Biol       Date:  2021-05-10

7.  Premature Ovarian Insufficiency (POI) Induced by Dynamic Intensity Modulated Radiation Therapy via P13K-AKT-FOXO3a in Rat Models.

Authors:  Lianli He; Xiaoqin Long; Nixiao Yu; Yajun Li; Xiaoyun Liu; Xiaoju Cheng
Journal:  Biomed Res Int       Date:  2021-06-29       Impact factor: 3.411

8.  Individual heterogeneity screened umbilical cord-derived mesenchymal stromal cells with high Treg promotion demonstrate improved recovery of mouse liver fibrosis.

Authors:  Yuanyuan Xie; Shuo Liu; Liudi Wang; Hui Yang; Chenxu Tai; Li Ling; Libo Chen; Shanshan Liu; Bin Wang
Journal:  Stem Cell Res Ther       Date:  2021-06-22       Impact factor: 6.832

Review 9.  Mesenchymal stem cells: ideal seeds for treating diseases.

Authors:  Guanwen Gao; Chenyang Fan; Weiquan Li; Runzhang Liang; Chuzhong Wei; Xiaojie Chen; Yue Yang; Yueyuan Zhong; Yingqi Shao; Yi Kong; Zesong Li; Xiao Zhu
Journal:  Hum Cell       Date:  2021-07-16       Impact factor: 4.374

Review 10.  Therapeutic Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Female Reproductive Diseases.

Authors:  Zhiqi Liao; Chang Liu; Lan Wang; Cong Sui; Hanwang Zhang
Journal:  Front Endocrinol (Lausanne)       Date:  2021-06-23       Impact factor: 5.555
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