Sangmin Lee1, Amy Metcalfe2,3,4, Maitreyi Raman5, Yvette Leung6, Fariba Aghajafari7,8, Nicole Letourneau7,9,10,11, Remo Panaccione12, Gilaad G Kaplan13, Cynthia H Seow14. 1. University of Calgary Cumming School of Medicine, Community Health Sciences, Calgary, AB, Canada. 2. University of Calgary Cumming School of Medicine, Calgary, AB, Canada. 3. Obstetrics & Gynecology, Calgary, AB, Canada. 4. Community Health Sciences, Medicine, Calgary, AB, Canada. 5. University of Calgary Cumming School of Medicine, Medicine, Calgary, AB, Canada. 6. University of British Columbia, Medicine, Vancouver, BC, Canada. 7. University of Calgary Cumming School of Medicine, Community Health Sciences, AB, Canada. 8. Family Medicine, Calgary, AB, Canada. 9. University of Calgary Cumming School of Medicine, Medicine, AB, Canada. 10. University of Calgary Cumming School of Medicine, Pediatrics & Psychiatry, AB, Canada. 11. University of Calgary Faculty of Nursing, Nursing, Calgary, AB, Canada. 12. University of Calgary, Inflammatory Bowel Disease Clinic, Calgary, AB, Canada. 13. University of Calgary, Division of Gastroenterology, Departments of Medicine, Calgary, AB, Canada. 14. University of Calgary, Department of Medicine, Calgary, AB, Canada.
Abstract
BACKGROUND AND AIMS: Vitamin D insufficiency is prevalent in individuals with inflammatory bowel disease [IBD], as well as in pregnant women; however, the prevalence of vitamin D insufficiency in pregnant women with IBD is unknown. This study assessed the prevalence of vitamin D insufficiency in pregnant women with IBD and the adequacy of recommended supplementation. METHODS: A cross-sectional study was conducted in pregnant women with inflammatory bowel disease [Crohn's disease = 61, ulcerative colitis = 41] and without inflammatory bowel disease [n = 574]. Chi square tests and log binomial regression were used to examine the prevalence of vitamin D insufficiency. Covariates included ethnicity and season. Adequacy of vitamin D supplementation during pregnancy was also assessed. RESULTS: The prevalence of vitamin D insufficiency [25-OHD ≤75 nmol/L] in those with Crohn's disease was 50.8% (95% confidence interval [CI]: 38.4%-63.2%) and 60.9% [95% CI: 45.3%-74.7%] with ulcerative colitis compared with 17.4% [95% CI: 14.6%-20.8%] without inflammatory bowel disease. Women with inflammatory bowel disease were more likely to be vitamin D insufficient after adjusting for ethnicity and season (Crohn's disease-adjusted relative risk [aRR] = 2.98,;: 2.19-4.04; ulcerative colitis-aRR = 3.61; 95% CI: 2.65-4.93). Despite vitamin D supplementation, 32.3% [95% CI: 17.8%-51.2%] of those with Crohn's disease, 58.3% [95% CI: 37.1%-76.9%] of those with with ulcerative colitis, and 10.8% [95% CI: 6.9%-16.6%] of those without inflammatory bowel disease were still vitamin D insufficient. CONCLUSIONS: Pregnant women with inflammatory bowel disease are at increased risk of vitamin D insufficiency compared with those without inflammatory bowel disease. The current guidelines for vitamin D supplementation may be inadequate for pregnant women with inflammatory bowel disease.
BACKGROUND AND AIMS: Vitamin D insufficiency is prevalent in individuals with inflammatory bowel disease [IBD], as well as in pregnant women; however, the prevalence of vitamin D insufficiency in pregnant women with IBD is unknown. This study assessed the prevalence of vitamin D insufficiency in pregnant women with IBD and the adequacy of recommended supplementation. METHODS: A cross-sectional study was conducted in pregnant women with inflammatory bowel disease [Crohn's disease = 61, ulcerative colitis = 41] and without inflammatory bowel disease [n = 574]. Chi square tests and log binomial regression were used to examine the prevalence of vitamin D insufficiency. Covariates included ethnicity and season. Adequacy of vitamin D supplementation during pregnancy was also assessed. RESULTS: The prevalence of vitamin D insufficiency [25-OHD ≤75 nmol/L] in those with Crohn's disease was 50.8% (95% confidence interval [CI]: 38.4%-63.2%) and 60.9% [95% CI: 45.3%-74.7%] with ulcerative colitis compared with 17.4% [95% CI: 14.6%-20.8%] without inflammatory bowel disease. Women with inflammatory bowel disease were more likely to be vitamin D insufficient after adjusting for ethnicity and season (Crohn's disease-adjusted relative risk [aRR] = 2.98,;: 2.19-4.04; ulcerative colitis-aRR = 3.61; 95% CI: 2.65-4.93). Despite vitamin D supplementation, 32.3% [95% CI: 17.8%-51.2%] of those with Crohn's disease, 58.3% [95% CI: 37.1%-76.9%] of those with with ulcerative colitis, and 10.8% [95% CI: 6.9%-16.6%] of those without inflammatory bowel disease were still vitamin D insufficient. CONCLUSIONS: Pregnant women with inflammatory bowel disease are at increased risk of vitamin D insufficiency compared with those without inflammatory bowel disease. The current guidelines for vitamin D supplementation may be inadequate for pregnant women with inflammatory bowel disease.
Authors: D McCarthy; P Duggan; M O'Brien; M Kiely; J McCarthy; F Shanahan; K D Cashman Journal: Aliment Pharmacol Ther Date: 2005-05-01 Impact factor: 8.171
Authors: Irene M van der Meer; Nasra S Karamali; A Joan P Boeke; Paul Lips; Barend J C Middelkoop; Irene Verhoeven; Jan D Wuister Journal: Am J Clin Nutr Date: 2006-08 Impact factor: 7.045