Literature DB >> 2954604

Inhibition of the sodium pump by cardioactive DPI 201-106.

A J Kaumann, D E Richards, D A Russell.   

Abstract

The effects of DPI 201-106 were examined on contractions of papillary muscles from the right ventricle of feline heart, on [3H]-ouabain binding and Na+, K+-ATPase activity in feline ventricular membrane particles and on ouabain-sensitive 86Rb uptake in human erythrocytes. DPI 201-106 partially inhibited the Na+ pump at concentrations that caused pronounced positive inotropic effects.

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Year:  1987        PMID： 2954604      PMCID： PMC1853489          DOI： 10.1111/j.1476-5381.1987.tb08975.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  Modification of single cardiac Na+ channels by DPI 201-106.

Authors:  M Kohlhardt; U Fröbe; J W Herzig
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

2.  Evidence for different receptor sites for the novel cardiotonic S-DPI 201-106, ATX II and veratridine on the cardiac sodium channel.

Authors:  G Scholtysik; U Quast; A Schaad
Journal:  Eur J Pharmacol       Date:  1986-06-05       Impact factor: 4.432

3.  Potentiation of the effects of isoprenaline and noradrenaline by hydrocortisone in cat heart muscle.

Authors:  A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

4.  Convenient apparatus for recording contractions of isolated heart muscle.

Authors:  J R Blinks
Journal:  J Appl Physiol       Date:  1965-07       Impact factor: 3.531

5.  Improved purification and partial characterization of (Na+, K+)-ATPase from cardiac muscle.

Authors:  B J Pitts; A Schwartz
Journal:  Biochim Biophys Acta       Date:  1975-08-20

6.  The role of sodium channels in the effects of the cardiotonic compound DPI 201-106 on contractility and membrane potentials in isolated mammalian heart preparations.

Authors:  D Buggisch; G Isenberg; U Ravens; G Scholtysik
Journal:  Eur J Pharmacol       Date:  1985-12-03       Impact factor: 4.432

7.  Antiarrhythmic effects of DPI 201-106.

Authors:  G Scholtysik; F M Williams
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739

8.  DPI 201-106, a novel cardioactive agent. Combination of cAMP-independent positive inotropic, negative chronotropic, action potential prolonging and coronary dilatory properties.

Authors:  G Scholtysik; R Salzmann; R Berthold; J W Herzig; U Quast; R Markstein
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-05       Impact factor: 3.000
  8 in total
  2 in total

Review 1.  New mechanisms for positive inotropic agents: focus on the discovery and development of imazodan.

Authors:  R E Weishaar; D Kobylarz-Singer; B A Klinkefus
Journal:  Cardiovasc Drugs Ther       Date:  1989-03       Impact factor: 3.727

2.  On minimum cyclic AMP formation rates associated with positive inotropic effects mediated through beta 1-adrenoceptors in kitten myocardium. Beta 1-specific and non-adrenergic stimulant effects of denopamine.

Authors:  H Lemoine; K J Teng; S J Slee; A J Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989 Jan-Feb       Impact factor: 3.000
  2 in total

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