Literature DB >> 2954507

Phosphofructokinase activity in the brain in Alzheimer's disease.

N R Sims, J P Blass, C Murphy, D M Bowen, D Neary.   

Abstract

The activity of phosphofructokinase, a key regulatory enzyme of glycolysis, was determined in neurosurgical samples of neocortex obtained from 6 patients with primary degenerative dementia, including 4 with Alzheimer's disease. No consistent reductions were seen compared with samples from nondemented controls. These results contrast with the greatly reduced activity reported previously for postmortem brain specimens from patients with Alzheimer's disease.

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Year:  1987        PMID： 2954507     DOI： 10.1002/ana.410210517

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  6 in total

Review 1.  Systemic and brain metabolic dysfunction as a new paradigm for approaching Alzheimer's dementia.

Authors:  Vincenzo Giordano; Gianfranco Peluso; Maurizio Iannuccelli; Paola Benatti; Raffaella Nicolai; Menotti Calvani
Journal:  Neurochem Res       Date:  2006-08-17       Impact factor: 3.996

2.  Bioenergetics breakdown in Alzheimer's disease: targets for new therapies.

Authors:  Uday Saxena
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2010-06-12

Review 3.  Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome.

Authors:  Alessandra C Martini; Thomas J Gross; Elizabeth Head; Mark Mapstone
Journal:  Neuron       Date:  2022-04-25       Impact factor: 18.688

4.  Analyses of energy metabolism and mitochondrial genome in post-mortem brain from patients with Alzheimer's disease.

Authors:  H Reichmann; S Flörke; G Hebenstreit; H Schrubar; P Riederer
Journal:  J Neurol       Date:  1993-06       Impact factor: 4.849

5.  Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type.

Authors:  S Hoyer; R Nitsch
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575

Review 6.  Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease.

Authors:  Federica Cioffi; Rayan Hassan Ibrahim Adam; Kerensa Broersen
Journal:  J Alzheimers Dis       Date:  2019       Impact factor: 4.472
  6 in total

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