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Literature DB >> 29544680

The role of ROS-induced autophagy in hepatocellular carcinoma.

Xingxing Yuan¹, Bingyu Wang¹, Lei Yang¹, Yali Zhang².

Abstract

Hepatocellular carcinoma (HCC) is a main cause of cancer-related mortality and its etiology is not fully understood. As prominent factors that regulate cellular homeostasis, both reactive oxygen species (ROS) and autophagy are considered to play an essential role in the liver carcinogenesis. However, the crosstalk between ROS and autophagy is not well characterized in the pathogenesis of HCC. This review summarizes the roles of autophagy in ROS-mediated hepatocarcinogenesis and discusses the role of ROS-induced autophagy in HCC cell fate decision following treatment with chemotherapeutic agents in preclinical settings, which may allow the identification of novel strategies for the treatment of HCC.

Entities: Chemical Disease

Keywords: Autophagy; Chemotherapy; Hepatocellular carcinoma (HCC); Pathogenesis; Reactive oxygen species (ROS)

Mesh：

Substances：

Year: 2018 PMID： 29544680 DOI： 10.1016/j.clinre.2018.01.005

Source DB: PubMed Journal: Clin Res Hepatol Gastroenterol ISSN： 2210-7401 Impact factor: 2.947

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Cited

16 in total

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2. Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.

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4. ROS-Mediated Anti-Tumor Effect of Coptidis Rhizoma against Human Hepatocellular Carcinoma Hep3B Cells and Xenografts.

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5. Ginsenoside Compound K Induces Ros-Mediated Apoptosis and Autophagic Inhibition in Human Neuroblastoma Cells In Vitro and In Vivo.

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7. Antiproliferative and Pro-Apoptotic Effect of Uvaol in Human Hepatocarcinoma HepG2 Cells by Affecting G0/G1 Cell Cycle Arrest, ROS Production and AKT/PI3K Signaling Pathway.

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